2. Membrane Transporter/Ion Channel Neuronal Signaling PI3K/Akt/mTOR
  3. iGluR mTOR
  4. Tulrampator

Tulrampator  (Synonyms: CX-1632; S-47445)

製品番号: HY-109046 純度: 99.39%
COA 取扱説明書 Technical Support

Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Tulrampator

Tulrampator 構造式

CAS 番号 : 1038984-31-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 59 在庫あり
Solution
10 mM * 1 mL in DMSO USD 59 在庫あり
Solid
5 mg $54 在庫あり
10 mg $88 在庫あり
25 mg $166 在庫あり
50 mg $265 在庫あり
100 mg $425 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Tulrampator:

Tulrampator 関連抗体

Top Publications Citing Use of Products

iGluR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
AMPA Receptor NMDA Receptor Kainate Receptor

mTOR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
mTOR mTORC1 mTORC2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].

IC50 & Target

AMPAR[1]
体外実験

Tulrampator (0.1 μM, 2 days) markedly enhances the amplitude of the glutamate-evoked current and prolongs the response in HEK-293 cells[1].
Tulrampator (0.1-10 μM, 24 h) shows absence of toxicity on rat primary cortical cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tulrampator 関連抗体

Cell Cytotoxicity Assay[1]

Cell Line: rat primary cortical cells
Concentration: 0.1 μM, 3 μM, 10 μM
Incubation Time: 24 h
Result: Did not potentiate glutamatemediated toxicity on rat primary cortical neuronal culture,at 0.03-100 μM glutamate.
体内実験

Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) has anxiolytic-like and antidepressant-like effects in the CORT Mice Model[2].
Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) reverts olfactory bulbectomy (OB)-induced hyperactivity and anxiety in bilateral olfactory bulbectomy mice model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: chronic corticosterone administration (CORT) mice[2]
Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Oral gavage (p.o.)
Result: Reversed anxio-depressive phenotype in a neurogenesis-dependent task.
Decreased the corticosterone-induced increase in emotionality.
Had a rapid onset of effect on anhedonia in the rat Chronic Mild Stress (CMS) model.
Stimulated cell proliferation, survival and neuronal maturation in the dentate gyrusof the hippocampus.
Animal Model: bilateral olfactory bulbectomy mice model[3]
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Significantly reverted OB-induced hyperactivity after 28 days.
Increased open field central activity in OB mice.
臨床実験
分子量

380.37

分子式

C20H17FN4O3
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(C1CC1)CO2)C3=C2C=C4C(N=NN(CCC5=CC(F)=CC=C5)C4=O)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 20 mg/mL (52.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6290 mL 13.1451 mL 26.2902 mL
5 mM 0.5258 mL 2.6290 mL 5.2580 mL
10 mM 0.2629 mL 1.3145 mL 2.6290 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.17 mg/mL (5.70 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.17 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.17 mg/mL (5.70 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6290 mL 13.1451 mL 26.2902 mL 65.7255 mL
5 mM 0.5258 mL 2.6290 mL 5.2580 mL 13.1451 mL
10 mM 0.2629 mL 1.3145 mL 2.6290 mL 6.5725 mL
15 mM 0.1753 mL 0.8763 mL 1.7527 mL 4.3817 mL
20 mM 0.1315 mL 0.6573 mL 1.3145 mL 3.2863 mL
25 mM 0.1052 mL 0.5258 mL 1.0516 mL 2.6290 mL
30 mM 0.0876 mL 0.4382 mL 0.8763 mL 2.1908 mL
40 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.6431 mL
50 mM 0.0526 mL 0.2629 mL 0.5258 mL 1.3145 mL
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Tulrampator Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tulrampator1038984-31-4CX-1632 S-47445CX1632CX 1632S47445S 47445S-47445iGluRmTORIonotropic glutamate receptorsMammalian target of RapamycinHEK-293 cellschronic corticosterone administrationbilateral olfactory bulbectomyprimary rat cortical cellsInhibitorinhibitorinhibit

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