1038984-31-4
Chemical Structure
Tulrampator
Synonym(s): CX-1632; S-47445
- CAS No.: 1038984-31-4
- Formula:C20H17FN4O3
- Molecular Weight:380.37
IUPAC Name: 8-cyclopropyl-3-(3-fluorophenethyl)-7,8-dihydro-3H-[1,3]oxazino[6',5':4,5]benzo[1,2-d][1,2,3]triazine-4,9-dione
InChIKey: JHCFQXNWYDLBOG-UHFFFAOYSA-N
SMILES: O=C(N(C1CC1)CO2)C3=C2C=C4C(N=NN(CCC5=CC(F)=CC=C5)C4=O)=C3
Biological Activity: Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].
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Tulrampator | 99.39% | Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder. | ||||||||||||||||||||
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Tulrampator (Standard) | ≥98% | Tulrampator (Standard) is the analytical standard of Tulrampator (HY-109046). This product is intended for research and analytical applications. Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder. | ||||||||||||||||||||
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References
- [1]. Bretin S, et al. Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors [J]. PLoS One, 2017, 12(9): e0184429.
- [2]. Mendez-David I, et al. S 47445 produces antidepressant-and anxiolytic-like effects through neurogenesis dependent and independent mechanisms [J]. Frontiers in pharmacology, 2017, 8: 462.
- [3]. Pilar-Cuellar F, et al. S 47445 counteracts the behavioral manifestations and hippocampal neuroplasticity changes in bulbectomized mice [J]. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019, 93: 205-213.
