1. Membrane Transporter/Ion Channel
    Anti-infection
    Cell Cycle/DNA Damage
  2. P2X Receptor
    Influenza Virus
    Topoisomerase
  3. Aurintricarboxylic acid

Aurintricarboxylic acid 

Cat. No.: HY-122575
Handling Instructions

Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway.Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM.

For research use only. We do not sell to patients.

Aurintricarboxylic acid Chemical Structure

Aurintricarboxylic acid Chemical Structure

CAS No. : 4431-00-9

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Estimated Time of Arrival: December 31
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Description

Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively[1]. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis[3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway[4].Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM[5].

IC50 & Target[1][3]

Topoisomerase II

 

rP2X1R

8.6 nM (IC50)

rP2X3R

72.9 nM (IC50)

Apoptosis

 

In Vitro

Aurintricarboxylic acid strongly inhibits rP2X1Rs and rP2X3Rs with IC50 values of 8.6 nM and 72.9 nM, respectively, and more weakly inhibits P2X2/3Rs, P2X2Rs, P2X4Rs or P2X7Rs[1].
Aurintricarboxylic acid inhibition of ATP-induced currents is concentration dependent[1].
Aurintricarboxylic acid is a non-competitive antagonist of P2X3R[1].
Aurintricarboxylic acid can inhibit the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and vaccinia virus[2].
Aurintricarboxylic acid protects MDCK cells from infection with influenza A strains PR8, NY or N[2].
Aurintricarboxylic acid inhibits replication of influenza A and B viruses[2].
Aurintricarboxylic acid inhibits neuraminidase activities of influenza A and B viruses[2].
Aurintricarboxylic acid inhibits TWEAK-Fn14-mediated NF-κB activation[4].
Aurintricarboxylic acid (10 μM;0.5-2 hours) suppresses TWEAK-Fn14-mediated NF-κB, Akt, and Src phosphorylation in GBM cells[4].
Aurintricarboxylic acid blocks TWEAK-stimulated Rac1 activation and TRAF2 recruitment to Fn14 cytoplasmic domain in glioma cells[4].
Aurintricarboxylic acid represses TWEAK-stimulated glioma cell migration and invasion without causing cell cytotoxicity[4].

Western Blot Analysis[4]

Cell Line: T98G, A172, GBM44 glioma cells
Concentration: 10 μM
Incubation Time: 0.5 hour, 1 hour, 2 hours
Result: Abrogated TWEAK activation of downstream signals including phosphorylation of the NF-κB family member p65, Akt, and Src in all three GBM cell lines.
Molecular Weight

422.34

Formula

C₂₂H₁₄O₉

CAS No.

4431-00-9

SMILES

O=C(C=C/1)C(C(O)=O)=CC1=C(C2=CC(C(O)=O)=C(O)C=C2)\C3=CC(C(O)=O)=C(O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (295.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3678 mL 11.8388 mL 23.6776 mL
5 mM 0.4736 mL 2.3678 mL 4.7355 mL
10 mM 0.2368 mL 1.1839 mL 2.3678 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Aurintricarboxylic acidP2X ReceptorInfluenza VirusTopoisomeraseP2XRsATP-gatedP2Xreceptorfamilysensoryneurotransmissionchroniccoughpainneuropathicanti-influenzatopoisomeraseglioblastomaTWEAK-Fn14TWEAKFn14Inhibitorinhibitorinhibit

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Aurintricarboxylic acid
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