2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK4/6-IN-20

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC50 values ​​of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research.

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CDK4/6-IN-20

CDK4/6-IN-20 Chemische Struktur

CAS. Nr. : 3033950-84-1

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CDK4/6-IN-20 Related Antibodies

Top Publications Citing Use of Products

Alle CDK Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Beschreibung

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC50 values ​​of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research[1].

IC50 & Target

CDK4

1.9 nM (IC50)

CDK6

14.2 nM (IC50)

In Vitro

CDK4/6-IN-20 inhibits the proliferation of MCF7 and T47D cells with IC50 values ​​of 169 and 92 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CDK4/6-IN-20 Related Antibodies
Molekulargewicht

421.47

Formel

C23H24FN5O2
CAS. Nr.
SMILES

O[C@@H]1COCC[C@H]1NC2=NC=C(C#N)C(C3=CC(C4(CCCC4)C(C)=N5)=C5C(F)=C3)=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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CDK4/6-IN-20 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-203033950-84-1CDKCyclin dependent kinase2-aminopyrimidine compoundcell proliferationMCF7 cellsT47D cellsInhibitorinhibitorinhibit

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