2. PI3K/Akt/mTOR Stem Cell/Wnt NF-κB Neuronal Signaling
  3. GSK-3 NF-κB Amyloid-β
  4. Cromolyn

Cromolyn  (Synonyms: Cromoglycate; Cromoglicic acid; FPL-670 free acid)

製品番号: HY-B1619 純度: 99.97%
COA 取扱説明書 Technical Support

Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 16110-51-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 26 在庫あり
Solution
10 mM * 1 mL in DMSO USD 26 在庫あり
Solid
5 mg $25 在庫あり
10 mg $40 在庫あり
25 mg $80 在庫あり
50 mg $125 在庫あり
100 mg $190 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Cromolyn:

Cromolyn 関連抗体

Top Publications Citing Use of Products

    Cromolyn purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Mar 10;43(3):446-463.e7.  [Abstract]

    Cromolyn disodium (DSCG: 10 mg/kg). Experimental workflow and tumor growth of the murine 4T1 breast tumor model. Data on day 15 were presented.

    Cromolyn purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Mar 10;43(3):446-463.e7.  [Abstract]

    Cromolyn disodium (DSCG: 10 mg/kg). GSVA scores of immune cell subsets after different treatments in the murine 4T1 breast tumor model.

    Cromolyn purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):509.  [Abstract]

    Cell viability of HT1080 S100P OE cells pretreated with indicated concentrations of Cromolyn disodium for 12 h and then treated with RSL3 (200 nM) for 6 h.

    Cromolyn purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.  [Abstract]

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

    GSK-3 アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    GSK-3 GSK-3α GSK-3β

    NF-κB アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5].

    Cellular Effect
    Cell Line Type Value Description References
    Sf21 IC50
    > 1000 μM
    Compound: Cromolyn
    Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    		[PMID: 21965623]
    Sf21 IC50
    > 1000 μM
    Compound: Cromolyn
    Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
    		[PMID: 21965623]
    体外実験

    Cromolyn (0-100 μM; 3-10 min) can inhibit IgE- and antigen-induced degranulation and PGD2 synthesis in rat peritoneal mast cells[1].
    Cromolyn (0-100 μM; 0-72 h) can block S100P-promoted cell proliferation, invasion, and increased NF-κB activity in Panc-1 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cromolyn 関連抗体
    体内実験

    Cromolyn (10 mg/kg; intravenous injection; single dose) can significantly inhibit mast cell activation in IgE-dependent PCA by reducing Evans blue extravasation and completely inhibit antigen-induced plasma histamine increase in PSA in rats[1].
    Cromolyn (5 mg/kg; intraperitoneal injection; 5 weeks) has anti-tumor activity in a mouse model of pancreatic cancer[2].
    Cromolyn (6.3 mg/kg; intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia) has an ameliorative effect in a model of amyotrophic lateral sclerosis[3].
    Cromolyn (1-3.15 mg/kg; intraperitoneal injection; 3 times a week; 12 weeks) has a neuroprotective effect in a mouse model of Alzheimer's disease[4].
    Cromolyn (1.43-5.72 mg/kg; intraperitoneal injection; 1 month) has a hypoglycemic effect in mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male CB17 scid mice aged 4 weeks old treated BxPC-3 and MPanc-96 cells[2]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 5 weeks
    Result: Significantly reduced tumor burden.
    Reduced lung metastasis in the BxPC-3 model and both liver and lung metastases in the MPanc-96 model.
    Had no effect on body weight.
    Animal Model: SOD1G93A mice[3]
    Dosage: 6.3 mg/kg
    Administration: Intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia
    Result: Delays disease onset.
    Improved motor deficits in the PaGE task.
    Increased survival of lumbar spinal cord motor neurons, decreased denervation at the neuromuscular junction.
    Reduced pro-inflammatory cytokine and chemokine levels in the spinal cord and plasma.
    Decreased mast cell degranulation in the tibialis anterior muscle.
    Animal Model: APPSwedish expressing Tg2576 mice[4]
    Dosage: 1 and 3.15 mg/kg
    Administration: Intraperitoneal injection; 3 times a week; 12 weeks
    Result: Reduced the levels of Aβ40 and Aβ42 in brain TBS-insoluble fractions.
    Increased the level of Aβ38.
    Promoted the phagocytosis of β-amyloid by microglia.
    Animal Model: Normal Balb/c mice, chronic type II diabetic Balb/c mice, and chronic obese Balb/c mice[5]
    Dosage: 1.43, 2.86 and 5.72 mg/kg
    Administration: Intraperitoneal injection; 1 month
    Result: Dose-dependently reducted blood glucose, body weight, and resistin levels.
    Increased liver glycogen, insulin, C-peptide, and adiponectin levels in mice.
    分子量

    468.37

    分子式

    C23H16O11
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    OC(COC1=C2C(C=C(C(O)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O)=O)OC4=CC=C3)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 175 mg/mL (373.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1351 mL 10.6753 mL 21.3506 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL
    10 mM 0.2135 mL 1.0675 mL 2.1351 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

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    濃度 （終了）

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    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 99.97%

    COA (245 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1351 mL 10.6753 mL 21.3506 mL 53.3766 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL 10.6753 mL
    10 mM 0.2135 mL 1.0675 mL 2.1351 mL 5.3377 mL
    15 mM 0.1423 mL 0.7117 mL 1.4234 mL 3.5584 mL
    20 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
    25 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1351 mL
    30 mM 0.0712 mL 0.3558 mL 0.7117 mL 1.7792 mL
    40 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
    50 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0675 mL
    60 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8896 mL
    80 mM 0.0267 mL 0.1334 mL 0.2669 mL 0.6672 mL
    100 mM 0.0214 mL 0.1068 mL 0.2135 mL 0.5338 mL
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    Cromolyn Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cromolyn16110-51-3Cromoglycate Cromoglicic acidFPL-670FPL670FPL 670GSK-3NF-κBAmyloid-βGlycogen synthase kinase-3Glycogen synthase kinase 3Nuclear factor-κBNuclear factor-kappaBβ-amyloid peptideAβAbetapancreatic cancer modelamyotrophic lateral sclerosis modelAlzheimer's disease modelrat peritoneal mast cellsPanc-1 cellsInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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