2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Mitochondrial Metabolism Caspase
  4. d-KLA Peptide

d-KLA Peptide  (Synonyms: D-(KLAKLAK)2)

Cat. No.: HY-P10285 Purity: 99.33%
COA
SDS
Handling Instructions Technical Support

d-KLA Peptide (D-(KLAKLAK)2), KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

d-KLA Peptide

d-KLA Peptide Chemical Structure

CAS No. : 286380-05-0

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Other Forms of d-KLA Peptide:

d-KLA Peptide Related Antibodies

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  • Purity & Documentation

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Description

d-KLA Peptide (D-(KLAKLAK)2), KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models[1].

IC50 & Target[1]

Caspase-3

 

Caspase-7

 

In Vitro

d-KLA Peptide (400 μM) kills 50% of eukaryotic cells in the monolayer[1].
d-KLA Peptide induces mitochondrial swelling in a cell-free system with an ED50 of 0.44 μM[1].
d-KLA Peptide induces mitochondrial membrane potential loss in a cell-free system with an ED50 of 0.4 μM[1].
d-KLA Peptide (1.5 μM in 1 μM ODN; 24 h) can form liposomes, which can reduce the viability of B16 (F10) mouse melanoma cells and enhance caspase 3/7 activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

d-KLA Peptide Related Antibodies
In Vivo

Cationic liposome-loaded d-KLA Peptide (1.52 µg)/G3139 (4 µg) (intratumoral; twice daily for 2 doses) provides significant antitumor efficacy in melanoma-bearing mice, achieving 60% tumor growth inhibition via enhanced apoptotic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, initial weight 24.4 g, subcutaneous B16(F10) melanoma model)[1]
Dosage: 1.52 µg with G3139 (4 µg) in cationic liposome
Administration: intratumoral; twice daily for 2 doses; intratumoral
Result: Reduced tumor volume increase to 186% by day 4 post-treatment, compared to 470% for untreated controls.
Achieved a tumor growth inhibition (TGI) of 60%.
Induced significant apoptosis in tumor tissues as evidenced by bright green staining of apoptotic nuclei in TUNEL assays.
Molecular Weight

1523.99

Formula

C72H138N20O15
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

d-{Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys}
Sequence Shortening

d-{KLAKLAKKLAKLAK}
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (16.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6562 mL 3.2809 mL 6.5617 mL
5 mM 0.1312 mL 0.6562 mL 1.3123 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.33%

SDS (252 KB)

COA (240 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6562 mL 3.2809 mL 6.5617 mL 16.4043 mL
5 mM 0.1312 mL 0.6562 mL 1.3123 mL 3.2809 mL
10 mM 0.0656 mL 0.3281 mL 0.6562 mL 1.6404 mL
15 mM 0.0437 mL 0.2187 mL 0.4374 mL 1.0936 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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d-KLA Peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

d-KLA Peptide286380-05-0D-(KLAKLAK)2ApoptosisMitochondrial MetabolismCaspasecancer cellsprokaryotic cytoplasmic membranesmouse melanoma modelscaspase 3/7mitochondrial membranesB16(F10) mouse melanoma cellsmitochondrial-dependent apoptosismelanomaapoptosiseukaryotic plasma membranesInhibitorinhibitorinhibit

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