2. Anti-infection
  3. Virus Protease
  4. Dipotassium glycyrrhizinate

Dipotassium glycyrrhizinate  (Synonyms: Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate)

製品番号: HY-N0184A 純度: 99.68%
COA 取扱説明書 Technical Support

Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity.

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CAS 番号 : 68797-35-3

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
50 mg $50 在庫あり
100 mg $80 在庫あり
500 mg $240 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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カスタマーレビュー

Based on 59 publication(s) in Google Scholar

Other Forms of Dipotassium glycyrrhizinate:

Dipotassium glycyrrhizinate 関連抗体

Top Publications Citing Use of Products

顧客検証

In Vivo Efficacy Study
WB
Histological Imaging/Staining
RT-PCR

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2025 May 1.

    The protein expression of P21, P16, Tom20, HMGB1, cGAS, and STING were assessed via western blotting with β-tubulin as a loading control. Data were expressed as mean ± SEM (n = 3). The results showed that Glycyrrhizic acid (10 μM; 24 h) significantly enhanced the anti-senescent effect of exosomes and inhibited the HMGB1/cGAS-STING axis.

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2024 Apr 4;43(1):105.  [Abstract]

    Glycyrrhizin (1 nM/kg; i.c.v.; administered every 3 days starting from day 14 after modeling). A, In a subcutaneous xenograft tumor model, the tumor volumes were measured and monitored every 7 days from each group of mice. (n = 4/group). B, The pictures of corresponding subcutaneous xenograft tumors dissected from each group mice at 42 days post-injection. C Tumor weights from each group at 42 days post-injection.

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Dec:135:156059.  [Abstract]

    qRT-PCR analysis of HSP90AB1 and HSP90AA1 in NOK cells after stimulation with LPS and HCQ (10 µM) or Glycyrrhiz (GL, 100 μg/mL) in for 24 h.

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Jan;13(2):e2301808.  [Abstract]

    Osteoinduction was hindered in Glycyrrhizic acid (GA, 10 mM; 30min) group.

    Dipotassium glycyrrhizinate purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2020 Jun;53(6):e12829.  [Abstract]

    Protein levels of pro-caspase-1 + p10 + p12, GADMD, IL-1β, IL-18 and NLRP3 are detected by Western blotting. Glycyrrhizin inhibits pyroptosis in TNF-α-induced M1 macrophages.

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    製品説明

    Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity[1][2][3].

    体外実験

    Dipotassium glycyrrhizinate (0-400 μM, 4 days) inhibits mRNA level of atopic dermatitis related genes (NELL2, CA2, AQP3, and HAS3 gene level) in IL‑4‑ and IL‑13‑induced keratinocytes[1].
    Dipotassium glycyrrhizinate (0-400 μM, 4 days) partially repaired the atopic dermatitis-like phenotype (the spongiosis like intercellular spaces) in the IL-4/IL-13-induced AD-like skin equivalent model[1].
    Dipotassium glycyrrhizinate (0-100 μM, 24 h) inhibits Sunitinib-induced autophagy, cardiomyocyte death in CCC-HEH-2 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Dipotassium glycyrrhizinate 関連抗体
    体内実験

    Dipotassium glycyrrhizinate (150 mg/kg, i.p.) reduces plasma glucose and increases plasma GLP-1 in Streptozotocin (65 mg/kg, i.p.) induced type 1-like diabetic rats[2].
    Dipotassium glycyrrhizinate (50 mg/kg, i.p., once daily for 4 weeks) inhibits thyroiditis in the Iodine-induced murine model of autoimmune thyroiditis[3].
    Dipotassium glycyrrhizinate (50-200 mg/kg, i.p.,) inhibits Bleomycin (HY-108345)-induced pulmonary fibrosis IN rats[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Iodine-induced murine model of autoimmune thyroiditis[3]
    Dosage: 50 mg/kg
    Administration: i.p., once daily for 4 weeks
    Result: Reduced serum levels of TgAb, HMGB1, TNF-α, IL-6, IL-1β.
    Decreased The prevalence of thyroiditis and the infiltration of lymphocytes, and attenuated the severity of thyroiditis.
    分子量

    899.11

    分子式

    C42H60K2O16
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[C@]12[C@@](C(C=C3[C@]2(CC[C@]4(C)[C@@]3([H])C[C@](C(O[K])=O)(C)CC4)C)=O)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O[K])=O)CC5)C)([H])CC1)C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (55.61 mM; Need ultrasonic)

    DMSO : 17.5 mg/mL (19.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1122 mL 5.5611 mL 11.1221 mL
    5 mM 0.2224 mL 1.1122 mL 2.2244 mL
    10 mM 0.1112 mL 0.5561 mL 1.1122 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 16.67 mg/mL (18.54 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.68%

    COA (256 KB) HNMR (308 KB) LCMS (84 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.1122 mL 5.5611 mL 11.1221 mL 27.8053 mL
    5 mM 0.2224 mL 1.1122 mL 2.2244 mL 5.5611 mL
    10 mM 0.1112 mL 0.5561 mL 1.1122 mL 2.7805 mL
    15 mM 0.0741 mL 0.3707 mL 0.7415 mL 1.8537 mL
    H2O 20 mM 0.0556 mL 0.2781 mL 0.5561 mL 1.3903 mL
    25 mM 0.0445 mL 0.2224 mL 0.4449 mL 1.1122 mL
    30 mM 0.0371 mL 0.1854 mL 0.3707 mL 0.9268 mL
    40 mM 0.0278 mL 0.1390 mL 0.2781 mL 0.6951 mL
    50 mM 0.0222 mL 0.1112 mL 0.2224 mL 0.5561 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Dipotassium glycyrrhizinate Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dipotassium glycyrrhizinate68797-35-3Glycyrrhizic acid dipotassium Dipotassium glycyrrhizateVirus ProteaseInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-N0184A
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