Ethambutol

Name: Ethambutol
Brand: MedChemExpress
SKU: HY-B0535
Rating: 5.0 (4 reviews)

製品番号: HY-B0535 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Ethambutol is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol can be used to establish animal models of hyperuricemia and optic neuropathy.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Ethambutol 構造式

CAS 番号 : 74-55-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 44	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 44	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$40	在庫あり	Estimated Time of Arrival: December 31
10 mg	$68	在庫あり	Estimated Time of Arrival: December 31
25 mg	$136	在庫あり	Estimated Time of Arrival: December 31
50 mg	$225	在庫あり	Estimated Time of Arrival: December 31
100 mg	$380	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Ethambutol:

Ethambutol-d₄ 在庫あり
Ethambutol-d₁₀ 在庫あり
Ethambutol dihydrochloride 在庫あり
Ethambutol-d₈ お問い合わせ
Ethambutol (Standard) お問い合わせ

顧客検証

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	CC₅₀	100 6 Compound: Ethambutol	Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 28712709]
BMDM	CC₅₀	100 6 Compound: Ethambutol	Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 28712709]
BMDM	CC₅₀	100 6 Compound: Ethambutol	Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against Swiss mouse BMDM assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 28712709]
HepG2	CC₅₀	> 400 6 Compound: EMB	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
HepG2	CC₅₀	>400 6 Compound: EMB	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
MRC5	CC₅₀	>10 6 Compound: EMB	Cytotoxicity against human MRC5 cells after 24 hrs Cytotoxicity against human MRC5 cells after 24 hrs	[PMID: 26254828]
HepG2	CC₅₀	> 1444 3 Compound: EMB	Cytotoxicity against human HepG2 cells assessed as reduction in cell population incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell population incubated for 48 hrs by MTT assay	[PMID: 37399709]
MRC5	CC₅₀	> 10 6 Compound: EMB	Cytotoxicity against human MRC5 cells after 24 hrs Cytotoxicity against human MRC5 cells after 24 hrs	[PMID: 26254828]
HepG2	CC₅₀	> 400 6 Compound: EMB	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
RAW264.7	CC₅₀	≥ 400 6 Compound: EMB	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
RAW264.7	CC₅₀	>= 400 6 Compound: EMB	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
THP-1	EC₅₀	5.38 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days	[PMID: 20231389]
THP-1	EC₅₀	5.38 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days	[PMID: 20231389]
THP-1	EC₅₀	7.93 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days	[PMID: 20231389]
THP-1	EC₅₀	7.93 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days	[PMID: 20231389]
Vero	CC₅₀	>500 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 22626551]
Vero	IC₅₀	> 150 6 Compound: ethambutol	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]
Vero	CC₅₀	1470 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21376586]
Vero	CC₅₀	> 188.5 3 Compound: Ethambutol	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay	10.1007/s00044-011-9638-9
Vero	CC₅₀	38.51 6 Compound: A, ETB	Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay	[PMID: 23474387]
Vero	IC₅₀	> 200 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30145051]
Vero	CC₅₀	>188.5 3 Compound: Ethambutol	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay	10.1007/s00044-011-9638-9
Vero	IC₅₀	> 305.9 3 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19942326]
Vero	IC₅₀	> 305.9 3 Compound: ethambutol	Cytotoxicity against Vero cells after 72 hrs by MTT assay Cytotoxicity against Vero cells after 72 hrs by MTT assay	[PMID: 17276683]
Vero	IC₅₀	>305.9 3 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19942326]
Vero	IC₅₀	> 50 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24044875]
Vero	IC₅₀	>62.5 6 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]
Vero	IC₅₀	>50 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24044875]
Vero	CC₅₀	> 500 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 22626551]
Vero	IC₅₀	>62.5 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24721315]
Vero	IC₅₀	> 6.25 6 Compound: Ethambutol	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]
Vero	IC₅₀	> 62.5 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24721315]
Vero	IC₅₀	>200 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30145051]
Vero	IC₅₀	> 62.5 6 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]
Vero	IC₅₀	390.93 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay	[PMID: 28844400]
J774.A1	CC₅₀	> 1444 3 Compound: EMB	Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell population incubated for 48 hrs by MTT assay Cytotoxicity against mouse J774.A1 cells assessed as reduction in cell population incubated for 48 hrs by MTT assay	[PMID: 37399709]
Vero	IC₅₀	>6.25 6 Compound: Ethambutol	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]
Vero	CC₅₀	1470 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21376586]
Vero	IC₅₀	>62.5 6 Compound: Etha	Cytotoxicity against Vero cell line Cytotoxicity against Vero cell line	[PMID: 16759086]
Vero	CC₅₀	38.51 6 Compound: A, ETB	Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay	[PMID: 23474387]
MRC5	CC₅₀	> 10 6 Compound: EMB	Cytotoxicity against human MRC5 cells after 24 hrs Cytotoxicity against human MRC5 cells after 24 hrs	[PMID: 26254828]
Vero	IC₅₀	>100 3 Compound: ethambutol	Cytotoxicity against Vero cells Cytotoxicity against Vero cells	[PMID: 17562368]
Vero	IC₅₀	390.93 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay	[PMID: 28844400]
RAW264.7	CC₅₀	>= 400 6 Compound: EMB	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 33940463]
Vero	IC₅₀	>150 6 Compound: ethambutol	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]
Vero	IC₅₀	>305.9 3 Compound: ethambutol	Cytotoxicity against Vero cells after 72 hrs by MTT assay Cytotoxicity against Vero cells after 72 hrs by MTT assay	[PMID: 17276683]
THP-1	EC₅₀	5.38 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as extracellular bacterial killing after 7 days	[PMID: 20231389]
THP-1	EC₅₀	7.93 10 Compound: Ethambutol	Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days Antimycobacterial activity against Mycobacterium avium ATCC 700898 infected in human THP1 cells assessed as intracellular bacterial killing after 7 days	[PMID: 20231389]
Vero	CC₅₀	1470 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 21376586]
Vero	CC₅₀	38.51 6 Compound: A, ETB	Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay Cytotoxicity against african green monkey Vero cells after 72 hrs by resazurin assay	[PMID: 23474387]
Vero	CC₅₀	641 3 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell population incubated for 48 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell population incubated for 48 hrs by MTT assay	[PMID: 37399709]
Vero	CC₅₀	> 188.5 3 Compound: Ethambutol	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as cell viability after 72 hr by MTT assay	10.1007/s00044-011-9638-9
Vero	CC₅₀	> 500 3 Compound: EMB	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 22626551]
Vero	IC₅₀	390.93 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by trypan blue staining based assay	[PMID: 28844400]
Vero	IC₅₀	> 100 3 Compound: ethambutol	Cytotoxicity against Vero cells Cytotoxicity against Vero cells	[PMID: 17562368]
Vero	IC₅₀	> 150 6 Compound: ethambutol	Cytotoxicity against Vero cells after 48 hrs by XTT method Cytotoxicity against Vero cells after 48 hrs by XTT method	[PMID: 17888665]
Vero	IC₅₀	> 200 6 Compound: EMB	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30145051]
Vero	IC₅₀	> 305.9 3 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 19942326]
Vero	IC₅₀	> 305.9 3 Compound: ethambutol	Cytotoxicity against Vero cells after 72 hrs by MTT assay Cytotoxicity against Vero cells after 72 hrs by MTT assay	[PMID: 17276683]
Vero	IC₅₀	> 50 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24044875]
Vero	IC₅₀	> 6.25 6 Compound: Ethambutol	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]
Vero	IC₅₀	> 62.5 6 Compound: Etha	Cytotoxicity against Vero cell line Cytotoxicity against Vero cell line	[PMID: 16759086]
Vero	IC₅₀	> 62.5 6 Compound: Ethambutol	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]
Vero	IC₅₀	> 62.5 6 Compound: Ethambutol	Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 24721315]

体内実験

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Ethambutol can be used in animal modeling to build a model of hyperuricemia.

1. Induction of Hyperuricaemic Disease^[4]^[5]

Background

Elevated uric acid levels can lead to crystal deposition and may cause gout, urolithiasis, and urate nephropathy. Ethambutol can cause increased uric acid levels by reducing renal uric acid clearance, ultimately leading to hyperuricemia

Specific Modeling Methods

Rat^[4]: Male • Wistar rats • SPF • 200-220 g
Administration: 250 mg/kg • intragastric administration • once daily for 23 days

Note

(1) Ethambutol-induced hyperuricemia model should be combined with adenine (HY-B0152) (100 mg/kg; gavage) to achieve better model construction effect^[4].
(2) Some compounds can synergistically promote uric acid production, such as: Ethanol and Vitamin B12 (HY-B0315)^[5].
(3) Ethambutol-induced hyperuricemia model can be controlled by xanthine oxidase inhibitors.

Modeling Indicators

Molecular changes: URAT1 level in kidney homogenate ↑, OAT1 level ↓.

Physiological changes: Serum uric acid level ↑; sparse cells, tissue cell number ↑, lymphocyte number ↓.

Pathological changes: Pathological damage and inflammatory response in the thymus and spleen; thymus atrophy, cortical medullary fusion; splenic sinus congestion, with iron-yellow deposits.

Opposite Product(s): Xanthine Oxidase Inhibitors

2. Induction of Optic Neuropathy^[6]

Background

Ethambutol treatment can cause binocular toxicity at certain doses and durations. There is currently no clear treatment to prevent damage to retinal neuronal cells in cases of Ethhambutol-induced optic neuropathy (EON).

Specific Modeling Methods

Rat: Wistar rats
Administration: 35 mg/kg/day (Ethambutol) • po • 30 days

Modeling Indicators

Molecular changes: Bcl-2, Caspase-3 expression levels ↑.

Pathological indicators: Ganglion cell damage, increased density of retinal ganglion cells (RGCs); thickening of the RGC cell layer due to vacuoles formed in the ganglion cell cytoplasm.

Opposite Product(s): Citicoline (HY-B0739)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

204.31

分子式

C₁₀H₂₄N₂O₂

CAS 番号

74-55-5

Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](NCCN[C@@H](CC)CO)CO

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : ≥ 200 mg/mL (978.90 mM)

DMSO : 100 mg/mL (489.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8945 mL	24.4726 mL	48.9452 mL
5 mM	0.9789 mL	4.8945 mL	9.7890 mL
10 mM	0.4895 mL	2.4473 mL	4.8945 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (277 KB) SDS (393 KB)

COA (243 KB) HNMR (140 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ethambutol. Tuberculosis (Edinb), 2008. 88(2): p. 102-5. [Content Brief]

[2]. Rastogi N, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33(3): p. 167-75. [Content Brief]

[3]. Kaur D, et al. Khuller, In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17(1): p. 51-5. [Content Brief]

[4]. Kang L, et al. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol. 2020 Oct 28;261:113054. [Content Brief]

[5]. Pham AQ, et al. Pyrazinamide-induced hyperuricemia. P T. 2014 Oct;39(10):695-715. [Content Brief]

[6]. Nusanti S, et al. The Effect of Citicoline on Ethambutol Optic Neuropathy: Histopathology and Immunohistochemistry Analysis of Retina Ganglion Cell Damage Level in Rat Model. J Ocul Pharmacol Ther. 2022 Oct;38(8):584-589. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	4.8945 mL	24.4726 mL	48.9452 mL	122.3631 mL
	5 mM	0.9789 mL	4.8945 mL	9.7890 mL	24.4726 mL
	10 mM	0.4895 mL	2.4473 mL	4.8945 mL	12.2363 mL
	15 mM	0.3263 mL	1.6315 mL	3.2630 mL	8.1575 mL
	20 mM	0.2447 mL	1.2236 mL	2.4473 mL	6.1182 mL
	25 mM	0.1958 mL	0.9789 mL	1.9578 mL	4.8945 mL
	30 mM	0.1632 mL	0.8158 mL	1.6315 mL	4.0788 mL
	40 mM	0.1224 mL	0.6118 mL	1.2236 mL	3.0591 mL
	50 mM	0.0979 mL	0.4895 mL	0.9789 mL	2.4473 mL
	60 mM	0.0816 mL	0.4079 mL	0.8158 mL	2.0394 mL
	80 mM	0.0612 mL	0.3059 mL	0.6118 mL	1.5295 mL
	100 mM	0.0489 mL	0.2447 mL	0.4895 mL	1.2236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Ethambutol Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethambutol74-55-5BacterialAntibioticInhibitorinhibitorinhibit

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Ethambutol

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Antibiotic アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ethambutol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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Ethambutol

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Other Forms of Ethambutol:

Ethambutol 関連抗体

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•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Antibiotic アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Ethambutol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report