Ethyl glucuronide

Name: Ethyl glucuronide
Brand: MedChemExpress
SKU: HY-113093
Rating: 4.5 (0 reviews)

Cat. No.: HY-113093 Purity: 99.22%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Ethyl glucuronide is an endogenous metabolite. Ethyl glucuronide is the metabolite of ethanol. Ethyl glucuronide is a biomarker for ethanol exposure that accumulates in hair and reflects the alcohol intake over a time period. Ethyl glucuronide is the agonist for TLR4.

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Ethyl glucuronide 화학구조

CAS No. : 17685-04-0

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Ethyl glucuronide:

Ethyl glucuronide-d₅ In-stock

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•Related Screening Libraries:

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View All Endogenous Metabolite Isoform Specific Products:

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Human Endogenous Metabolite Microbial Metabolite

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

Ethyl glucuronide (0-100 μM, 24 h) blocks the formation of TLR4-MD2 complex, stimulates the expression of TLR4-depenent SEAP protein in HEK-TLR4 cell^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ethyl glucuronide (0.38 µg, intrathecal injection, single dose) reduces the tactile threshold, induces hyperalgesia in Sprague-Dawley rat models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rat models^[2]
Dosage:	0.38 µg
Administration:	intrathecal injection, single dose
Result:	Reduced the tactile threshold.

Clinical Trial

분자량

222.19

화학식

C₈H₁₄O₇

CAS No.

17685-04-0

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H]1[C@H]([C@@H]([C@@H](O)[C@H](OCC)O1)O)O)=O

Structure Classification

Saccharides

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

H₂O : 125 mg/mL (562.57 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5006 mL	22.5030 mL	45.0059 mL
5 mM	0.9001 mL	4.5006 mL	9.0012 mL
10 mM	0.4501 mL	2.2503 mL	4.5006 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.22%

Select Batch:

Data Sheet (277 KB) SDS (394 KB)

COA (253 KB) HNMR (262 KB) LCMS (88 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Małkowska A, et al., The influence of caffeine on ethyl glucuronide levels in rat serum and in rat hair. Pharmacol Rep. 2018 Oct;70(5):831-836. [Content Brief]

[2]. Lewis SS, et al., Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain Behav Immun. 2013 May;30:24-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.5006 mL	22.5030 mL	45.0059 mL	112.5148 mL
	5 mM	0.9001 mL	4.5006 mL	9.0012 mL	22.5030 mL
	10 mM	0.4501 mL	2.2503 mL	4.5006 mL	11.2515 mL
	15 mM	0.3000 mL	1.5002 mL	3.0004 mL	7.5010 mL
	20 mM	0.2250 mL	1.1251 mL	2.2503 mL	5.6257 mL
	25 mM	0.1800 mL	0.9001 mL	1.8002 mL	4.5006 mL
	30 mM	0.1500 mL	0.7501 mL	1.5002 mL	3.7505 mL
	40 mM	0.1125 mL	0.5626 mL	1.1251 mL	2.8129 mL
	50 mM	0.0900 mL	0.4501 mL	0.9001 mL	2.2503 mL
	60 mM	0.0750 mL	0.3750 mL	0.7501 mL	1.8752 mL
	80 mM	0.0563 mL	0.2813 mL	0.5626 mL	1.4064 mL
	100 mM	0.0450 mL	0.2250 mL	0.4501 mL	1.1251 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.