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  4. Kainic acid hydrate

Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures.

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Kainic acid hydrate Chemical Structure

Kainic acid hydrate Chemical Structure

CAS No. : 58002-62-3

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Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].

In Vivo

Kainic acid hydrate (5 mg/kg; i.p.; hourly at least 3 h until status epilepticus) induces seizures in rats[1].The kainic acid induced seizures model is a good tool to study temporal lobe epilepsy. The model can be reproduced in a variety of species through either systemic, intrahippocampal or intra-amygdaloid administrations. The systemic Kainic acid administration induced model is similar with human temporal lobe epilepsy (TLE)[4][6]. Kainic acid (5 nmoles, injections into the neostriatum, substantia nigra or cerebellum) shows that more than half of the compound disappeared from the injection site and the brain by 1/2 hour post injection, and less than radioactivity of 7 pmol/mg of tissue were found in other areas[3].
Induction of epilepsy model[5]
Kainic acid, an analog of L-glutamate and an ionotropic KA receptor agonist, can damage hippocampal pyramidal neurons.
Specific Mmodeling Methods
Mice: C57BL/6J • male • 7 weeks old • 22 g body weight
Administration: 10 μg in 5 μL • i.c.v.
(1) The right lateral brain ventricle is localized with a stereotactic instrument.
(2) After the operation, skin was sutured, and keep the mice under a warming place until they wake up.
(3) 48 hours after lateral ventricle injection, the mice are anaesthetized using Isoflurane and then sequentially intracardially perfused with saline and PFA (4%, 30 mL). Rapidly remove The mouse brain processed for paraffin embedding or frozen sections.

Modeling Indicators
Electroencephalogram (EEG) recording: Had higher local maximal amplitude and reduced spike frequency compared to the control group.
Histology analysis: Showed Triangulated pyknotic nuclei and cytoplasmic shrinkage in the hippocampal neuron, and induced neuronal loss.
Opposite Product(s): Sitagliptin (HY-13749)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks, 200-250 g male adult Wistar rats[1]
Dosage: 5 mg/kg
Administration: I.p.; hourly at least 3 h until status epilepticus
Result: Induced seizures in rats.
Molecular Weight







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