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  5. Kainic acid hydrate

Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures.

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CAS No. : 58002-62-3

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Based on 35 publication(s) in Google Scholar

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Top Publications Citing Use of Products

35 Publications Citing Use of MCE Kainic acid hydrate

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    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2025 Jul;28(7):1404-1417.  [Abstract]

    Kainic Acid (KA, i.p., 24 mg/kg, single dose in mouse model of TLE) administration markedly increased microglial calcium signal in both brain regions.

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 29:e08161.  [Abstract]

    ROCK2 inhibition reversed KA (50 μM)-induced suppression of mitophagy, suggesting mitochondrial normalization.

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332.  [Abstract]

    In the TFP@A-treated group, the number and duration of GS were significantly reduced by the second day of Kainic acid (KA, 0.5 mg/mL, 0.5 µL) treatment, with antiepileptic effects lasting until the third day

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Transl Psychiatry. 2025 May 17;15(1):172.  [Abstract]

    KA treatment: Lidocaine (3%) and KA (2 mg/mL) were infused bilaterally into the LC via delivery cannulas connected to the cannula drug delivery system in a 0.2 μL volume per side at a rate of 0.1 μL/10 s 30 min after training. Pharmacological inhibition of the LC reduced conditioned fear memory in mice, whereas activation of the LC reversed the SGB-induced reduction in conditioned fear memory [n = 8, F (3, 28) = 53.26, P < 0.0001; NS + Vehicle vs. NS + Lid, n = 8, P < 0.0001; SGB + Vehicle vs. SGB + KA, n = 8, P < 0.0001].

    Kainic acid hydrate purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 Apr;26(4):542-554.  [Abstract]

    At the chronic stage (21 d after i.p., 24 mg/kg KA injection), both PLIN2/BD493 staining and electron microscopy of mouse hippocampus showed accumulation of LDs in neurons and astrocytes but not in microglia or oligodendrocytes.

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    Description

    Kainic acid hydrate is a potent excitotoxic agent. Kainic acid hydrate also is an agonist for a subtype of ionotropic glutamate receptor. Kainic acid hydrate induces seizures[1][2].

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Kainic acid can be used to create epilepsy models and can be administered systemically, into the hippocampus, or amygdala, and is reproducible in various species. The systemic Kainic acid model closely mimics the manifestations of human temporal lobe epilepsy. When injected at a dose of 5 nM into the neostriatum, substantia nigra, or cerebellum, over half of the Kainic acid disappears from the injection site and brain within 0.5 hours, with radioactivity detected in other brain regions at concentrations lower than 7 pmol/mg[3][4][6].

    Induction of epilepsy model[5]
    Background
    Kainic acid, an analog of L-glutamate and an ionotropic KA receptor agonist, can damage hippocampal pyramidal neurons.
    Specific Modeling Methods
    Mice: C57BL/6J • male • 7 weeks old • 22 g body weight
    Administration: 10 μg in 5 μL • i.c.v.
    Note
    (1) The right lateral brain ventricle is localized with a stereotactic instrument.
    (2) After the operation, skin was sutured, and keep the mice under a warming place until they wake up.
    (3) 48 hours after lateral ventricle injection, the mice are anaesthetized using Isoflurane and then sequentially intracardially perfused with saline and PFA (4%, 30 mL). Rapidly remove The mouse brain processed for paraffin embedding or frozen sections.
    Modeling Indicators
    Electroencephalogram (EEG) recording: Had higher local maximal amplitude and reduced spike frequency compared to the control group.
    Histology analysis: Showed Triangulated pyknotic nuclei and cytoplasmic shrinkage in the hippocampal neuron, and induced neuronal loss.
    Opposite Product(s): Sitagliptin (HY-13749)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 8 weeks, 200-250 g male adult Wistar rats[1]
    Dosage: 5 mg/kg
    Administration: I.p.; hourly at least 3 h until status epilepticus
    Result: Induced seizures in rats.
    Molecular Weight

    231.25

    Formula

    C10H17NO5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)=C.O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Purity & Documentation
    References
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    Kainic acid hydrate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Kainic acid58002-62-3mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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