2. Anti-infection Apoptosis
  3. Influenza Virus HSV HCV Apoptosis Caspase
  4. Moroxydine

Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

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Moroxydine

Moroxydine 화학구조

CAS No. : 3731-59-7

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Moroxydine Related Antibodies

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제품 설명

Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].

IC50 & Target[1]

Caspase 3

 

Cellular Effect
Cell Line Type Value Description References
Vero C1008 IC50
>2.0 × 105M
Compound: COVC-1214483276
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
10.6019/CHEMBL4651402
In Vitro

Moroxydine hydrochloride (HY-B0420A) used in papers

Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells (TC50 = 1246.0 μg/mL, SC = 218.5 μg/mL) and grass carp ovary (GCO) cells (TC50 = 117.2 μg/mL, SC = 140.9 μg/mL)[1][2].

Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against giant salamander iridovirus (GSIV) in epithelioma papulosum cyprinid (EPC) cells, with a TC50 of 1486.3 μg/mL and a safe concentration (SC) of 209.7 μg/mL[2].

Moroxydine (40 μg/mL, 48-96 h) blocks the virus-induced CPE and cell death within 96 h and maintained the normal structure and nucleocapsids[1].

Moroxydine (40 μg/mL, 48-96 h) significantly decreases the apoptosis in CIK cells (GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].

Moroxydine (12-48 h) significantly inhibits the caspase 3 activity, Bax expression and down-regulates Bcl-2 at 48 h in CIK cells[1].

Moroxydine (20 μg/mL, 12-72 h) shows time-dependent suppression of viral gene expression in CIK cells(GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].

Moroxydine (20 μg/mL, 72 h) arrests cell cycle in the period of G1/S and G2/M of CIK cells[3].

Moroxydine (3-7 days) inhibits the GCRV-induced upregulation of immune genes (IL-1β, IFN-I, TNF-α) in the kidney, liver, muscle and gill[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Moroxydine Related Antibodies

Cell Viability Assay[1]

Cell Line: GCRV infected CIK cells
Concentration: 1, 2.5, 6.3, 15.9, 39.8, 100 μg/mL
Incubation Time: 24, 48, 72, 96 h
Result: Presented a better protective-efficiency than Ribavirin(HY-B0434).
Showed no significant difference when expose GCRV-infected CIK cells in 39.8 μg/mL compared with virus-free group at 96 h.

Apoptosis Analysis[1]

Cell Line: GCRV infected CIK cells
Concentration: 40 μg/mL
Incubation Time: 48 h
Result: Exhibited a positive inhibition in the GCRV infected cells compared with negative control.

Cell Cycle Analysis[3]

Cell Line: GCRV infected CIK cells
Concentration: 20 μg/mL
Incubation Time: 72 h
Result: Arrested cell cycle in the period of G1/S and G2/M of CIK cells

Real Time qPCR[1][3]

Cell Line: GCRV infected CIK cells
Concentration: 20 μg/mL
Incubation Time: 12, 24, 48, 72 h
Result: Suppressed viral genes (vp1, vp2, vp3 and vp4) at 12 h following a slow decrease from 12 h to 72 h post medication.
Inhibited the IL-1β expression.
분자량

171.20

화학식

C6H13N5O
CAS No.
SMILES

N=C(NC(N1CCOCC1)=N)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
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Moroxydine Related Classifications

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Keywords:

Moroxydine3731-59-7ABOBInfluenza VirusHSVHCVApoptosisCaspaseHerpes simplex virusHepatitis C virusCIK cellsGCO cellsEPC cellsGCRVGSIVapoptosisinfluenza virusherpes simplexvaricella zostermeaslesmumps diseasehepatitis C virusInhibitorinhibitorinhibit

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