2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Anti-infection
  3. Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
  4. Oligomycin

Oligomycin  (Synonyms: オリゴマイシン)

製品番号: HY-N6782 純度: 98.64%
COA 取扱説明書 Technical Support

Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.

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CAS 番号 : 1404-19-9

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
2 mg $78 在庫あり
5 mg $130 在庫あり
10 mg $188 在庫あり
25 mg $410 在庫あり
50 mg $742 在庫あり
100 mg $1300 在庫あり
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Based on 105 publication(s) in Google Scholar

Other Forms of Oligomycin:

Oligomycin 関連抗体

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顧客検証

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Cell Imaging/Staining

    Oligomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 13:e2413376.  [Abstract]

    Fluorescence images of cellular ROS levels: NanoMassage ameliorate ROS generation and cell apoptosis induced by CCCP or Oligomycin (10 μM, 1 h) in neuron-like cells.

    Oligomycin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jan 2:S2090-1232(24)00623-4.  [Abstract]

    Real-time analysis of the OCR was carried out with a Seahorse analyser with single cells from mice liver tissues following treatment with Oligomycin (1.5 μM).

    Oligomycin purchased from MedChemExpress. Usage Cited in: Cell. 2024 Apr 25;187(9):2269-2287.e16.  [Abstract]

    Abundance of BRCA2, γH2AX protein, and MG-H1 adduct formation in HeLa Kyoto cells after treatment with Oligomycin (1 μM) for 4, 24, and 48 h.

    Oligomycin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 8;15(1):8723.  [Abstract]

    qRT-PCR analysis of Chop and Asns mRNA levels in seven-month-old C57BL/6J male and female mice treated with DMSO or Oligomycin (0.5 mg/kg, ip).

    Oligomycin purchased from MedChemExpress. Usage Cited in: J Am Chem Soc. 2023 Oct 18;145(41):22433-22441.  [Abstract]

    Typical curves showing temperature fluctuations of individual cells at different time intervals in the absence of stimulus (black) and after the addition of Oligomycin (blue) (100 μM).

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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    製品説明

    Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells[1][2][3][4].

    体外実験

    Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Oligomycin 関連抗体
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@](O)(C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@H](CC)CC[C@]2([H])O[C@@]3(O[C@@H](C[C@H](O)C)[C@@H](C)CC3)[C@H]([C@@](O1)([H])[C@@H]2C)C)=O)=O.O=C4/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@]5([H])O[C@@]6(O[C@](C[C@H](O)C)([H])[C@@H](C)CC6)[C@H]([C@@](O4)([H])[C@@H]5C)C)=O)=O
    Structure Classification
    Initial Source

    Streptomyces
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    Ethanol : 30 mg/mL (Need ultrasonic and warming)

    DMSO : 20 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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    純度とドキュメンテーション

    純度: ≥99.0%

    COA (248 KB) HNMR (483 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Oligomycin Related Classifications

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oligomycin1404-19-9Oxidative PhosphorylationATP SynthaseFungalAntibioticoxidativephosphorylationelectrontransportchainrespiratorycomplex VHIF-1alphaInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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