2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Anti-infection
  3. Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
  4. Oligomycin

Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.

For research use only. We do not sell to patients.

CAS No. : 1404-19-9

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Based on 105 publication(s) in Google Scholar

Other Forms of Oligomycin:

Oligomycin Related Antibodies

Top Publications Citing Use of Products

105 Publications Citing Use of MCE Oligomycin

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Cell Imaging/Staining

    Oligomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 13:e2413376.  [Abstract]

    Fluorescence images of cellular ROS levels: NanoMassage ameliorate ROS generation and cell apoptosis induced by CCCP or Oligomycin (10 μM, 1 h) in neuron-like cells.

    Oligomycin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jan 2:S2090-1232(24)00623-4.  [Abstract]

    Real-time analysis of the OCR was carried out with a Seahorse analyser with single cells from mice liver tissues following treatment with Oligomycin (1.5 μM).

    Oligomycin purchased from MedChemExpress. Usage Cited in: Cell. 2024 Apr 25;187(9):2269-2287.e16.  [Abstract]

    Abundance of BRCA2, γH2AX protein, and MG-H1 adduct formation in HeLa Kyoto cells after treatment with Oligomycin (1 μM) for 4, 24, and 48 h.

    Oligomycin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 8;15(1):8723.  [Abstract]

    qRT-PCR analysis of Chop and Asns mRNA levels in seven-month-old C57BL/6J male and female mice treated with DMSO or Oligomycin (0.5 mg/kg, ip).

    Oligomycin purchased from MedChemExpress. Usage Cited in: J Am Chem Soc. 2023 Oct 18;145(41):22433-22441.  [Abstract]

    Typical curves showing temperature fluctuations of individual cells at different time intervals in the absence of stimulus (black) and after the addition of Oligomycin (blue) (100 μM).

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    Description

    Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells[1][2][3][4].

    In Vitro

    Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Oligomycin Related Antibodies
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@](O)(C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@H](CC)CC[C@]2([H])O[C@@]3(O[C@@H](C[C@H](O)C)[C@@H](C)CC3)[C@H]([C@@](O1)([H])[C@@H]2C)C)=O)=O.O=C4/C=C/[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)[C@@H](O)[C@H](C)C([C@@H](C)[C@@H](O)[C@H](C)C/C=C/C=C/[C@@](CC)([H])CC[C@]5([H])O[C@@]6(O[C@](C[C@H](O)C)([H])[C@@H](C)CC6)[C@H]([C@@](O4)([H])[C@@H]5C)C)=O)=O
    Structure Classification
    Initial Source

    Streptomyces
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : 30 mg/mL (Need ultrasonic and warming)

    DMSO : 20 mg/mL (Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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    Purity & Documentation

    Purity: ≥99.0%

    SDS (420 KB)

    COA (248 KB) HNMR (483 KB)

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    Oligomycin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oligomycin1404-19-9Oxidative PhosphorylationATP SynthaseFungalAntibioticoxidativephosphorylationelectrontransportchainrespiratorycomplex VHIF-1alphaInhibitorinhibitorinhibit

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