2. Anti-infection Apoptosis Autophagy
  3. Bacterial Apoptosis Autophagy Antibiotic
  4. Patulin

パツリン  (Synonyms: Patulin; Terinin)

製品番号: HY-N6779 純度: 99.94%
COA 取扱説明書 Technical Support

Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage.

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Patulin

パツリン 構造式

CAS 番号 : 149-29-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 220 在庫あり
Solution
10 mM * 1 mL in DMSO USD 220 在庫あり
Solid
1 mg $70 在庫あり
5 mg $200 在庫あり
10 mg $380 在庫あり
25 mg $760 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Other Forms of Patulin:

パツリン 関連抗体

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製品説明

Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage[1][2][3][4].

体外実験

Patulin (2 μM, 6-24 h) induces LMP and reduces Cathepsin B release in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) increases cytochrome c protein level and leads apoptosis induction in an autophagy-dependent manner in HepG2 cells[3].
Patulin (2 μM, 6-24 h) impairs mitophagy in HepG2 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

パツリン 関連抗体

Apoptosis Analysis[3]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 6-24 h
Result: Increased the levels of active cleaved caspase-3 at 12 or 24 h.

Western Blot Analysis[3]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 3-24 h
Result: Increases the LC3-II levels.

Immunofluorescence[3]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 6-24 h
Result: Increased the numbers of swollen mitochondria with scarce or disordered cristae.
体内実験

Patulin (1-3.75 mg/kg, i.p., once time) induces DNA damage in the brain, liver and kidneys in a dose-dependent manner in CF-1 mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CF-1 mice[4]
Dosage: 1-3.75 mg/kg
Administration: i.p., once time
Result: Increased the damage index and TBARS production in the brain, liver and kidneys of mice in a dose-dependently manner (2.5-3.75 mg/kg).
Reduced the concentration of the reduced form of intracellular glutathione in the brain, liver and kidneys of mice at a dose of 2.5-3.75 mg/kg.
Decreased the levels of GSH.
Increased lipid peroxidation.
分子量

154.12

分子式

C7H6O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1OC2=CCOC(C2=C1)O
Structure Classification
Initial Source

Penicillium and Aspergillus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (648.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (324.42 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4885 mL 32.4423 mL 64.8845 mL
5 mM 1.2977 mL 6.4885 mL 12.9769 mL
10 mM 0.6488 mL 3.2442 mL 6.4885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (16.22 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.94%

COA (251 KB) HNMR (241 KB) LCMS (101 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.4885 mL 32.4423 mL 64.8845 mL 162.2113 mL
5 mM 1.2977 mL 6.4885 mL 12.9769 mL 32.4423 mL
10 mM 0.6488 mL 3.2442 mL 6.4885 mL 16.2211 mL
15 mM 0.4326 mL 2.1628 mL 4.3256 mL 10.8141 mL
20 mM 0.3244 mL 1.6221 mL 3.2442 mL 8.1106 mL
25 mM 0.2595 mL 1.2977 mL 2.5954 mL 6.4885 mL
30 mM 0.2163 mL 1.0814 mL 2.1628 mL 5.4070 mL
40 mM 0.1622 mL 0.8111 mL 1.6221 mL 4.0553 mL
50 mM 0.1298 mL 0.6488 mL 1.2977 mL 3.2442 mL
60 mM 0.1081 mL 0.5407 mL 1.0814 mL 2.7035 mL
80 mM 0.0811 mL 0.4055 mL 0.8111 mL 2.0276 mL
100 mM 0.0649 mL 0.3244 mL 0.6488 mL 1.6221 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Patulin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patulin149-29-1TerininBacterialApoptosisAutophagyAntibioticHepG2 cellsmycotoxincytotoxicclastogenicmutagenicteratogenicapoptosisInhibitorinhibitorinhibit

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