2. PI3K/Akt/mTOR NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Quinone Reductase Akt Reactive Oxygen Species (ROS) Apoptosis
  4. KP372-1

KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer).

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KP372-1

KP372-1 화학구조

CAS No. : 1374996-60-7

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of KP372-1:

KP372-1 Related Antibodies

Top Publications Citing Use of Products

View All Akt Isoform Specific Products:

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Akt Akt1 Akt2 Akt3

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer)[1][2][3].

In Vitro

KP372-1 (0.0625, 0.125, 0.25, 0.5, 1.0 μM; 48 h) inhibits growth of JMARc42 and Tu167c2 cells with IC50s of 200 and 100 nM, respectively[1].
KP372-1 (125 nM; 24 h) induces Tu167c2 cells apoptosis and induces anoikis in the JMARc42 cells[1].
KP372-1 (125 nM; 30 min) blocks Akt, thereby decreasing the phosphorylation of the S6 ribosomal protein in both Tu167 and JMAR cells[1].
KP372-1 (0.250, 0.5, 1.0 μM; 30 min) inhibits Akt kinase activity with an IC50 of 250 nM in JMAR cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KP372-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: JMARc42 and Tu167c2 cells
Concentration: 0.0625, 0.125, 0.25, 0.5, 1.0 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity.

Apoptosis Analysis[1]

Cell Line: Tu167c2 and JMARc42 cells
Concentration: 125 nM
Incubation Time: 24 h
Result: Induced approximately 90% of cells apoptosis.

Western Blot Analysis[1]

Cell Line: Tu167 and JMAR cells
Concentration: 125 nM
Incubation Time: 30 min
Result: Induced a small but consistent decrease in Akt phosphorylation with a concomitant marked decrease in S6 phosphorylation.
Inhibited the EGF induced phosphorylation of Aktser473 in Tu167 and AktThr308 in JMAR.

Western Blot Analysis[1]

Cell Line: JMAR cells
Concentration: 0.250, 0.5, 1.0 µM
Incubation Time: 30 min
Result: Significantly blocked Akt kinase activity in a dose-dependent fashion, with an IC50 of 250 nM.
In Vivo

KP372-1(10, 20 mg/kg; p.o.; single daily for 33 days) induces NADH oxidation and impairs tumor growth in vivo without apparent toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (H1299 xenografts model)[2].
Dosage: 10, 20 mg/kg
Administration: intragastric injection; single daily for 33 days
Result: Affected tumor metabolism and suppressed tumor growth.
분자량

448.36

화학식

C20H8N12O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(C3=NC4=NN=NN4N=C31)C=CC=C2.O=C5C6=NC7=NN=NN7N=C6C8=C5C=CC=C8
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
용액&용해도
In Vitro: 

DMSO : 17.86 mg/mL (39.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2304 mL 11.1518 mL 22.3035 mL
5 mM 0.4461 mL 2.2304 mL 4.4607 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.5%

SDS (392 KB)

COA (263 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2304 mL 11.1518 mL 22.3035 mL 55.7588 mL
5 mM 0.4461 mL 2.2304 mL 4.4607 mL 11.1518 mL
10 mM 0.2230 mL 1.1152 mL 2.2304 mL 5.5759 mL
15 mM 0.1487 mL 0.7435 mL 1.4869 mL 3.7173 mL
20 mM 0.1115 mL 0.5576 mL 1.1152 mL 2.7879 mL
25 mM 0.0892 mL 0.4461 mL 0.8921 mL 2.2304 mL
30 mM 0.0743 mL 0.3717 mL 0.7435 mL 1.8586 mL
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KP372-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KP372-11374996-60-7Quinone ReductaseAktReactive Oxygen Species (ROS)ApoptosisPKBProtein kinase Bpancreatic cancerHNSCCJMARc42Tu167c2Tu167cancerROSapoptosisInhibitorinhibitorinhibit

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상품명:
KP372-1
Cat. No.:
HY-15673
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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