PDK1/Akt/Flt dual pathway inhibitor
PDK1/Akt/Flt dual pathway inhibitor is one of a component of KP372-1 (HY-15673 ), and inhibits PDK1/Akt/Flt dual pathway.
For research use only. We do not sell to patients.
- CAS No.: 331253-86-2
- Formula: C10H4N6O
- Molecular Weight:224.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-3800
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
[PMID: 18579783] |
Chemical Information
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CAS No. 331253-86-2
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Molecular Weight 224.18
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Formula C10H4N6O
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SMILES
O=C1C2=C(C3=NC4=NN=NN4N=C31)C=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 20 mg/mL (89.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4607 mL | 22.3035 mL | 44.6070 mL | 111.5175 mL |
| 5 mM | 0.8921 mL | 4.4607 mL | 8.9214 mL | 22.3035 mL | |
| 10 mM | 0.4461 mL | 2.2304 mL | 4.4607 mL | 11.1518 mL | |
| 15 mM | 0.2974 mL | 1.4869 mL | 2.9738 mL | 7.4345 mL | |
| 20 mM | 0.2230 mL | 1.1152 mL | 2.2304 mL | 5.5759 mL | |
| 25 mM | 0.1784 mL | 0.8921 mL | 1.7843 mL | 4.4607 mL | |
| 30 mM | 0.1487 mL | 0.7435 mL | 1.4869 mL | 3.7173 mL | |
| 40 mM | 0.1115 mL | 0.5576 mL | 1.1152 mL | 2.7879 mL | |
| 50 mM | 0.0892 mL | 0.4461 mL | 0.8921 mL | 2.2304 mL | |
| 60 mM | 0.0743 mL | 0.3717 mL | 0.7435 mL | 1.8586 mL | |
| 80 mM | 0.0558 mL | 0.2788 mL | 0.5576 mL | 1.3940 mL |