2. Apoptosis Neuronal Signaling Membrane Transporter/Ion Channel
  3. Caspase Apoptosis iGluR
  4. PEAQX

PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures.

It is advisable to consider the salt form (PEAQX tetrasodium hydrate) that retains the same biological activity.

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CAS No. : 459836-30-7

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PEAQX Related Antibodies

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    PEAQX purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 Nov 1:391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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    AMPA Receptor NMDA Receptor Kainate Receptor

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    Description

    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
    IC50 & Target

    NMDA Receptor

     

    In Vitro

    PEAQX (3 μM) can induce cell apoptosis and promote caspase-3 activation in cortical striatal slice cultures[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PEAQX Related Antibodies
    In Vivo

    PEAQX (10-40 mg/kg; s.c.) can increase caspase-3 activity and enhance motor activity in the frontal cortex and striatum of rats in a dose-dependent manner[2].
    PEAQX (10 mg/kg; once daily; i.p.) can block the CaMKIV-TORC1-CREB pathway signal induced by sigma-1 receptor (σ 1r) agonists in mice with cerebral ischemia and improve learning and memory impairments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Pups obtained from deliveries of pregnant female Sprague-Dawley rats[2].
    Dosage: 10, 20, 40 mg/kg
    Administration: Subcutaneous injection (s.c.)
    Result: Resulted in an 8-fold increase in caspase-3 activity in the striatum when administered at a dose of 20 mg/kg.
    Animal Model: 11-week old C57BL/6 mice with cerebral ischemia[3].
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection (i.p.); once daily; 4 days
    Result: Reduced protein expression levels in the CaMKIV-TORC1-p-CREB-BDNF pathway.
    Masse moléculaire

    454.21

    Formule

    C17H17BrN3O5P
    CAS No.
    SMILES

    O=C1C(NC2=C(C(C(P(O)(O)=O)N[C@H](C3=CC=C(Br)C=C3)C)=CC=C2)N1)=O
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvant et solubilité

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    In Vivo:

    The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

    • Protocol 1

      PEAQX is dissolved in DMSO and diluted with sterile saline[3].

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PEAQX459836-30-7NVP-AAM077CaspaseApoptosisiGluRIonotropic glutamate receptorsorally activeNMDAcaspase-3cerebral ischemialearning disorderInhibitorinhibitorinhibit

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