1. Membrane Transporter/Ion Channel
  2. Sodium Channel
    Potassium Channel
  3. Ropivacaine

Ropivacaine 

Cat. No.: HY-B0563 Purity: 99.68%
Handling Instructions

Ropivacain is a potent sodium channel blocker and acts as a local anesthetic agent. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of regional anesthesia and neuropathic pain management.

For research use only. We do not sell to patients.

Ropivacaine Chemical Structure

Ropivacaine Chemical Structure

CAS No. : 84057-95-4

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Based on 1 publication(s) in Google Scholar

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Description

Ropivacain is a potent sodium channel blocker and acts as a local anesthetic agent. Ropivacain blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is used for the research of regional anesthesia and neuropathic pain management[1].

IC50 & Target

IC50: sodium ion influx[1]
IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)[2]

In Vivo

Epidural administration of Ropivacaine effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1].
Ropivacaine inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2].
Ropivacaine prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2].
Ropivacaine inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2].

Animal Model: Adult Sprague-Dawley rats (300–400g)[1]
Dosage: 1 μM
Administration: Infusion (added to the perfusate reservoir)
Result: Attenuated pressure-dependent increases in filtration coefficient (Kf).
Molecular Weight

274.40

Formula

C₁₇H₂₆N₂O

CAS No.

84057-95-4

SMILES

O=C([[email protected]]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (45.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6443 mL 18.2216 mL 36.4431 mL
5 mM 0.7289 mL 3.6443 mL 7.2886 mL
10 mM 0.3644 mL 1.8222 mL 3.6443 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.68%

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Keywords:

RopivacaineSodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAanaestheticneuronalconductionneuropathicpainK(2P)TREK-1potassiumchannelhypertensionvasoconstrictiveInhibitorinhibitorinhibit

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