Cat. No.: HY-B0563C

Ropivacaine mesylate

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane.

For research use only. We do not sell to patients.

Purity: 99.51%
CAS No.: 854056-07-8
Formula: C₁₈H₃₀N₂O₄S
Molecular Weight:370.51

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Ropivacaine mesylate Chemical Structure

CAS No.: 854056-07-8

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup^[1]^[2]. Ropivacaine is also an inhibitor of K_2P (two-pore domain potassium channel) TREK-1 with an IC₅₀ of 402.7 μM in COS-7 cell's membrane^[3].

IC₅₀ & Target

IC50: sodium ion influx^[1]
IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)^[3]

All Sodium Channel Isoforms :

In Vivo

Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury^[1].
Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)^[2].
Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats^[2].
Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult Sprague-Dawley rats (300-400g)^[2]
Dosage:

1 μM
Administration:

Infusion (added to the perfusate reservoir)
Result:

Attenuated pressure-dependent increases in filtration coefficient (K_f).

Chemical Information

CAS No. 854056-07-8
Appearance Solid
Molecular Weight 370.51
Formula C₁₈H₃₀N₂O₄S
Color White to off-white
SMILES

O=C([C@H]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (8)

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J Exp Clin Cancer Res

Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer. [Abstract]

2024 Mar 25;43(1):90. PMID: 38523299
Stem Cell Res Ther

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. [Abstract]

2021 Feb 4;12(1):107. PMID: 33541421
Int Immunopharmacol

Exploring the mechanism of ropivacaine in alleviating neuropathic pain via the mTOR-PKM2/STAT3-H4K12 lactylation axis. [Abstract]

2026 May 14:182:116838. PMID: 42134294
Int J Neuropsychopharmacol

Mechanism of the AMPK/SIRT1 pathway in gut dysbiosis-mediated postoperative cognitive dysfunction in aged mice. [Abstract]

2025 Oct 1;28(10):pyaf066. PMID: 41031618
Eur Spine J

Effect of species, concentration and volume of local anesthetics on intervertebral disk degeneration in rats with discoblock. [Abstract]

2022 Nov;31(11):2960-2971. PMID: 36152221
BMC Pregnancy Childbirth

KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension. [Abstract]

2025 Jun 2;25(1):646. PMID: 40457264
In Vitro Cell Dev Biol Anim

Inhibition of FOXO3 ameliorates ropivacaine-induced nerve cell damage through the miR-126-5p/TRAF6 axis. [Abstract]

2024 Oct;60(9):1109-1120. PMID: 39227495
J Toxicol Sci

Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway. [Abstract]

2023;48(3):139-148. PMID: 36858639

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (674.75 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6990 mL

13.4949 mL

26.9898 mL

5 mM

0.5398 mL

2.6990 mL

5.3980 mL

10 mM

0.2699 mL

1.3495 mL

2.6990 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321. [Content Brief]

[2]. Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28. [Content Brief]

[3]. Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717. [Content Brief]

[4]. Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.6990 mL	13.4949 mL	26.9898 mL	67.4746 mL
	5 mM	0.5398 mL	2.6990 mL	5.3980 mL	13.4949 mL
	10 mM	0.2699 mL	1.3495 mL	2.6990 mL	6.7475 mL
	15 mM	0.1799 mL	0.8997 mL	1.7993 mL	4.4983 mL
	20 mM	0.1349 mL	0.6747 mL	1.3495 mL	3.3737 mL
	25 mM	0.1080 mL	0.5398 mL	1.0796 mL	2.6990 mL
	30 mM	0.0900 mL	0.4498 mL	0.8997 mL	2.2492 mL
	40 mM	0.0675 mL	0.3374 mL	0.6747 mL	1.6869 mL
	50 mM	0.0540 mL	0.2699 mL	0.5398 mL	1.3495 mL
	60 mM	0.0450 mL	0.2249 mL	0.4498 mL	1.1246 mL
	80 mM	0.0337 mL	0.1687 mL	0.3374 mL	0.8434 mL
	100 mM	0.0270 mL	0.1349 mL	0.2699 mL	0.6747 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Ropivacaine mesylate

8 Cited Publications

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Ropivacaine mesylate

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Publications Citing Use of MedChemExpress (MCE) Ropivacaine mesylate

All Sodium Channel Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ropivacaine mesylate Related Classifications

HY-B0563C Related Classifications