1. Membrane Transporter/Ion Channel
  2. Sodium Channel
    Potassium Channel
  3. Ropivacaine mesylate

Ropivacaine mesylate 

Cat. No.: HY-B0563C Purity: >98.0%
Handling Instructions

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>[1]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.

For research use only. We do not sell to patients.

Ropivacaine mesylate Chemical Structure

Ropivacaine mesylate Chemical Structure

CAS No. : 854056-07-8

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Based on 1 publication(s) in Google Scholar

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Description

Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3].

IC50 & Target

IC50: sodium ion influx[1]
IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)[3]

In Vivo

Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1].
Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2].
Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2].
Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2].

Animal Model: Adult Sprague-Dawley rats (300-400g)[2]
Dosage: 1 μM
Administration: Infusion (added to the perfusate reservoir)
Result: Attenuated pressure-dependent increases in filtration coefficient (Kf).
Molecular Weight

370.51

Formula

C₁₈H₃₀N₂O₄S

CAS No.

854056-07-8

SMILES

O=C([[email protected]]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (674.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6990 mL 13.4949 mL 26.9898 mL
5 mM 0.5398 mL 2.6990 mL 5.3980 mL
10 mM 0.2699 mL 1.3495 mL 2.6990 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

RopivacaineSodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAneuronalconductionneuropathicpainK(2P)TREK-1potassiumchannelhypertensionvasoconstrictiveanaestheticInhibitorinhibitorinhibit

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Ropivacaine mesylate
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