1. Membrane Transporter/Ion Channel
  2. Sodium Channel
    Potassium Channel
  3. Ropivacaine hydrochloride

Ropivacaine hydrochloride 

Cat. No.: HY-B0563B Purity: 98.66%
Handling Instructions

Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo.

For research use only. We do not sell to patients.

Ropivacaine hydrochloride Chemical Structure

Ropivacaine hydrochloride Chemical Structure

CAS No. : 98717-15-8

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Based on 1 publication(s) in Google Scholar

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Description

Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is a local anesthetic agent widely used for regional anesthesia and neuropathic pain management in vivo[1].

IC50 & Target

IC50: sodium ion influx[1]
IC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)[3]

In Vivo

Epidural administration of Ropivacaine hydrochloride effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1].
Ropivacaine hydrochloride inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2].
Ropivacaine hydrochloride prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2].
Ropivacaine hydrochloride inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley rats (300–400g)[2]
Dosage: 1 μM
Administration: Infusion (added to the perfusate reservoir)
Result: Attenuated pressure-dependent increases in filtration coefficient (Kf).
Clinical Trial
Molecular Weight

310.86

Formula

C₁₇H₂₇ClN₂O

CAS No.

98717-15-8

SMILES

[H]Cl.O=C([[email protected]]1N(CCC)CCCC1)NC2=C(C)C=CC=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (32.17 mM; Need ultrasonic)

H2O : 10 mg/mL (32.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2169 mL 16.0844 mL 32.1688 mL
5 mM 0.6434 mL 3.2169 mL 6.4338 mL
10 mM 0.3217 mL 1.6084 mL 3.2169 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (3.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (3.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RopivacaineSodium ChannelPotassium ChannelNa channelsNa+ channelsKcsAanaestheticneuronalconductionneuropathicpainK(2P)TREK-1potassiumchannelhypertensionvasoconstrictiveInhibitorinhibitorinhibit

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Ropivacaine hydrochloride
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