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Results for "

(S)-( )-Arginine

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amino Acid Derivatives (4) Antibiotic (1) Apoptosis (2) Bacterial (3) Discoidin Domain Receptor (1) Endogenous Metabolite (16) Environmental Pollutants (1) FGFR (1) Fungal (1) Histone Acetyltransferase (1) Histone Methyltransferase (17) Isotope-Labeled Compounds (6) LPL Receptor (1) NO Synthase (15) Parasite (3) Phosphodiesterase (PDE) (3) PROTACs (1) Protease Activated Receptor (PAR) (2) Proteasome (1) Reference Standards (4) Ser/Thr Protease (2) Sirtuin (1) α-synuclein (1)
研究分野別:	Cancer (23) Cardiovascular Disease (3) Infection (9) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Solubilizing Agents (1)

阻害剤およびアゴニスト

ペプチド

天然物

同位体標識化合物

オリゴヌクレオチド

Targets Recommended: SRPK Protein Arginine Deiminase

製品番号	製品名	Target	研究分野	構造式

HY-N0455

L-Arginine 20+ Cited Publications	Environmental Pollutants Endogenous Metabolite NO Synthase	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-129047

Trypsin 15+ Cited Publications	Ser/Thr Protease Protease Activated Receptor (PAR)	Infection Inflammation/Immunology
Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin activates PAR2 and PAR4. Trypsin induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin also promotes cell proliferation and differentiation. Trypsin can be used in the research of wound healing and neurogenic inflammation .

HY-N0455A

*L-Arginine* hydrochloride** Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	NO Synthase Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-19615

MS023 20+ Cited Publications	Histone Methyltransferase	Cancer
MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-129047A

Trypsin (MS grade)	Ser/Thr Protease Protease Activated Receptor (PAR)	Infection Inflammation/Immunology
Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation .

HY-N0455AS8

*L-Arginine-13C6,15N4 hydrochloride* (S)-(+)-Arginine-13C6,15N4 hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹³C₆, ¹⁵N₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-128717A

GSK3368715 dihydrochloride 15+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717

GSK3368715 15+ Cited Publications EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-N0455AS2

*L-Arginine-d7 hydrochloride* (S)-(+)-Arginine-d7 hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine-d₇ (hydrochloride) is the deuterium labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS6

*L-Arginine-13C6 hydrochloride* (S)-(+)-Arginine-13C6 hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹³C₆ (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS1

*L-Arginine-15N4 hydrochloride* (S)-(+)-Arginine-15N4 hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹⁵N₄ (hydrochloride) is the ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis .

HY-18962

AMI-1 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-N0455B

*L-Arginine* (L-glutamate)** Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine (L-glutamate)	Endogenous Metabolite NO Synthase	Metabolic Disease
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .

HY-110137

Furamidine dihydrochloride 3 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1** over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

HY-N0455R

*L-Arginine* (Standard)**	Reference Standards NO Synthase Endogenous Metabolite	Cardiovascular Disease Cancer
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-19615B

MS023 dihydrochloride 20+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-N0455AS7

*L-Arginine-13C hydrochloride* (S)-(+)-Arginine-13C hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹³C (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS3

*L-Arginine-1-13C hydrochloride* (S)-(+)-Arginine-1-13C hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine-1- ¹³C (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-W013305

(S)-2-((tert-Butoxycarbonyl)amino)-5-guanidinopentanoic acid	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-5-guanidinopentanoic acid is an arginine derivative .

HY-23020

Boc3Arg	Proteasome	Cancer
Boc3Arg is the tert-butyl carbamate-protected arginine. Boc3Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome .

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .

HY-18962A

AMI-1 free acid 5+ Cited Publications	Histone Methyltransferase	Cancer
AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of *protein arginine* N-methyltransferases (PRMTs), with IC₅₀**s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-N0455AS5

*L-Arginine-1,2-13C2 hydrochloride* (S)-(+)-Arginine-1,2-13C2 hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine-1,2- ¹³C₂ (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-W105809R

*L-Arginine* L-aspartate (Standard)** (S)-2-Amino-5-((diaminomethylene)amino)pentanoic acid compound with L-aspartic acid (1:1) (Standard)	Reference Standards
L-Arginine L-aspartate (Standard) is the analytical standard of L-Arginine L-aspartate. This product is intended for research and analytical applications.

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective *protein arginine* methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for PRMT1** over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent .

HY-N0455AS4

*L-Arginine-13C6,15N4,d7 hydrochloride* (S)-(+)-Arginine-13C6,15N4,d7 hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹³C₆, ¹⁵N₄,d₇ (hydrochloride) is the deuterium, ¹³C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-W010913

(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-tosylguanidino)pentanoic acid	Amino Acid Derivatives	Others
(S)-2-((tert-Butoxycarbonyl)amino)-5-(3-tosylguanidino)pentanoic acid is an arginine derivative .

HY-135432

Etrasimod arginine 1 Publications Verification APD334 Arginine	LPL Receptor	Inflammation/Immunology
Etrasimod arginine is an orally available *S1P* receptor modulator that is a potent full agonist of the *S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine* reduces inflammation in a CD4 ⁺CD45RB ^high T cell-transferred mouse colitis model .

HY-N0455AS

*L-Arginine-15N2 hydrochloride* 1 Publications Verification (S)-(+)-Arginine-15N2 hydrochloride	NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹⁵N₂ (hydrochloride) is the ¹⁵N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455D

*L-Arginine* butanoate** Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine butanoate	Amino Acid Derivatives	Others
L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations .

HY-N0455AR

*L-Arginine* hydrochloride (Standard)** (S)-(+)-Arginine hydrochloride (Standard)	Reference Standards NO Synthase Endogenous Metabolite	Cancer
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-14926A

*Levonadifloxacin arginine* hydrate** (S)-(-)-Nadifloxacin Arginine hydrate; WCK-771A Arginine hydrate	Antibiotic Bacterial	Infection
Levonadifloxacin (arginine) hydrate is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin (arginine) hydrate shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes .

HY-175821

PRMT1-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT1-IN-3 is a potent protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 4.11 μM. PRMT1-IN-3 inhibits PRMT6 and PRMT8 with *IC₅₀s of 23.3 and 30.1 μM. PRMT1-IN-3 suppresses asymmetric dimethylarginine (ADMA) levels and histone H4R3me2a* modification in triple-negative breast cancer (TNBC) cells. PRMT1-IN-3 induces cell cycle arrest, apoptosis, and inhibits migration and colony formation in MDA-MB-231 cells. PRMT1-IN-3 acts as chemotherapeutic sensitizers for Paclitaxel (HY-B0015). PRMT1-IN-3 can be used for the study of TNBC .

HY-14926B

Levonadifloxacin arginine (S)-(-)-Nadifloxacin Arginine; WCK 771 Arginine	Bacterial	Infection
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells .

HY-N0455AS11

*L-Arginine-13C6,d14 hydrochloride* (S)-(+)-Arginine-13C6,d14 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Cancer
L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with ¹³C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator .

HY-N0455AS9

*L-Arginine-15N4,d7 hydrochloride* (S)-(+)-Arginine-15N4,d7 hydrochloride	Isotope-Labeled Compounds NO Synthase Endogenous Metabolite	Others
L-Arginine- ¹⁵N₄,d₇ (hydrochloride) is the deuterium and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-122008

ORM-3819	Bacterial	Infection
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) arginine is a broad-spectrum antistaphylococcal agent. Levonadifloxacin arginine has antimicrobial activity against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus and reduces phagocytosis of MRSA and MSSA strains by monocytic THP-1.

HY-W128037

(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride	Amino Acid Derivatives	Others
(S)-N-(1-Amino-5-guanidino-1-oxopentan-2-yl)benzamide hydrochloride is an arginine derivative .

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive *type I protein arginine* methyltransferases (PRMTs) inhibitor (IC₅₀*=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine* methylation states, alters exon usage, and has strong anti-cancer activity .

HY-155154

PRMT4-IN-2	Histone Methyltransferase	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with *IC₅₀*s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human *type I protein arginine* methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8**, respectively .

HY-172922

FGFR-IN-19	FGFR	Cancer
Arg-IN-1 is a selective Arginine (Arg)-targeting covalent inhibitor with *IC₅₀*s of 9.7 nM and 30.4 nM for FGFR2 and FGFR3,respectively. Arg-IN-1 has the potential to avoid FGFR1/4-targeted toxicity as well as conquer acquired on-target resistance, potential for FGFR-targeting cancer therapy .

HY-18962R

AMI-1 (Standard)	Histone Methyltransferase	Cancer
AMI-1 (Standard) is the analytical standard of AMI-1. This product is intended for research and analytical applications. AMI-1 is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-18962AR

AMI-1 free acid (Standard)	Histone Methyltransferase	Cancer
AMI-1 (free acid) (Standard) is the analytical standard of AMI-1 (free acid). This product is intended for research and analytical applications. AMI-1 free acid is a potent, cell-permeable and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with IC50s of 8.8 μM and 3.0 μM for human PRMT1 and yeast-Hmt1p, respectively. AMI-1 free acid exerts PRMTs inhibitory effects by blocking peptide-substrate binding .

HY-172732

PRMT5-IN-50	Histone Methyltransferase	Cancer
PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with *IC₅₀s value of 1.0, 536 nM for arginine* symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice .

HY-110137R

Furamidine dihydrochloride (Standard) DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)	Histone Methyltransferase Phosphodiesterase (PDE) Parasite Reference Standards	Infection Inflammation/Immunology Cancer
Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

HY-114510

PRMT/HKMT-IN-1	Discoidin Domain Receptor Histone Acetyltransferase Sirtuin Fungal Apoptosis	Infection Cancer
PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC₅₀ of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1, p300/CBP HAT, CARM1, SET7, SIRT1 and SIRT2. PRMT/HKMT-IN-1 inhibits methylation of histone H3K4, H4R3, and H3R17 residues. CBP/p300-IN-23 induces apoptosis, arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia .

HY-180976

Arg-PEG1-Tαsyn	PROTACs α-synuclein	Neurological Disease
Arg-PEG1-Tαsyn is an α-syn PROTAC degrader with a DC₅₀ of 0.28 μM in U251 cells. Arg-PEG1-Tαsyn employs the amino acid arginine (Arg) as the E3 ligase UBR1 ligand and a benzothiazole-aniline variant as the warhead for α-syn. Arg-PEG1-Tαsyn significantly reduces α-syn aggregates and improves the dopaminergic neuronal impairment and the locomotion with safety profile in vivo.Arg-PEG1-Tαsyn shows the high degradation effect in mammalian cells for both wild-type α-syn and the α-syn (A53T) mutant. Arg-PEG1-Tαsyn can be used for Parkinson’s disease research .

製品番号	製品名	Category	Target	構造式

HY-N0455

L-Arginine 20+ Cited Publications	Cardiovascular Disease Structural Classification Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Endogenous Metabolite NO Synthase
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455A

*L-Arginine* hydrochloride** Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine hydrochloride	天然物 Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	NO Synthase Endogenous Metabolite
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455B

*L-Arginine* (L-glutamate)** Maximum Cited Publications 23 Publications Verification (S)-(+)-Arginine (L-glutamate)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite NO Synthase
L-Arginine L-glutamate ((S)-(+)-Arginine L-glutamate) is the nitrogen donor for synthesis of nitric oxide. L-Arginine L-glutamate can be used for upper gastrointestinal hypofunction or dysfunction like functional dyspepsia research .

HY-N0455R

*L-Arginine* (Standard)**	Structural Classification Human Gut Microbiota Metabolites Microorganisms Amino acids Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

HY-N0455AR

*L-Arginine* hydrochloride (Standard)** (S)-(+)-Arginine hydrochloride (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Reference Standards NO Synthase Endogenous Metabolite
L-Arginine (hydrochloride) (Standard) is the analytical standard of L-Arginine (hydrochloride). This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

製品番号	製品名	構造式

HY-N0455AS8

*L-Arginine-13C6,15N4 hydrochloride*
L-Arginine- ¹³C₆, ¹⁵N₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS2

*L-Arginine-d7 hydrochloride*
L-Arginine-d₇ (hydrochloride) is the deuterium labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS6

*L-Arginine-13C6 hydrochloride*
L-Arginine- ¹³C₆ (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS1

*L-Arginine-15N4 hydrochloride*
L-Arginine- ¹⁵N₄ (hydrochloride) is the ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis .

HY-N0455AS7

*L-Arginine-13C hydrochloride*
L-Arginine- ¹³C (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS3

*L-Arginine-1-13C hydrochloride*
L-Arginine-1- ¹³C (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS5

*L-Arginine-1,2-13C2 hydrochloride*
L-Arginine-1,2- ¹³C₂ (hydrochloride) is the ¹³C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS4

*L-Arginine-13C6,15N4,d7 hydrochloride*
L-Arginine- ¹³C₆, ¹⁵N₄,d₇ (hydrochloride) is the deuterium, ¹³C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS

*L-Arginine-15N2 hydrochloride* 1 Publications Verification
L-Arginine- ¹⁵N₂ (hydrochloride) is the ¹⁵N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

HY-N0455AS11

*L-Arginine-13C6,d14 hydrochloride*
L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with ¹³C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator .

HY-N0455AS9

*L-Arginine-15N4,d7 hydrochloride*
L-Arginine- ¹⁵N₄,d₇ (hydrochloride) is the deuterium and ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

製品番号	製品名		Classification

HY-N0455

L-Arginine 20+ Cited Publications		Solubilizing Agents
L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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