L-Arginine-15N2 hydrochloride
Based on 1 publication(s) in Google Scholar
L-Arginine-15N2 (hydrochloride) is the 15N-labeled L-Arginine (hydrochloride). L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
For research use only. We do not sell to patients.
- Purity : 99.97%
- CAS No.: 204633-92-1
- Formula: C6H15ClN215N2O2
- Molecular Weight:212.65
-
Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Arginine-15N2 hydrochloride
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 204633-92-1
-
Unlabeled CAS 1119-34-2
-
Appearance Solid
-
Molecular Weight 212.65
-
Formula C6H15ClN215N2O2
-
Color White to off-white
-
SMILES
N[C@H](C(O)=O)CCCNC([15NH2])=[15NH].Cl
-
Synonyms
(S)-(+)-Arginine-15N2 hydrochloride
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
In Vitro:
H2O : ≥ 25 mg/mL (117.56 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [Content Brief]
[3]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [Content Brief]
[4]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.7026 mL | 23.5128 mL | 47.0256 mL | 117.5641 mL |
| 5 mM | 0.9405 mL | 4.7026 mL | 9.4051 mL | 23.5128 mL | |
| 10 mM | 0.4703 mL | 2.3513 mL | 4.7026 mL | 11.7564 mL | |
| 15 mM | 0.3135 mL | 1.5675 mL | 3.1350 mL | 7.8376 mL | |
| 20 mM | 0.2351 mL | 1.1756 mL | 2.3513 mL | 5.8782 mL | |
| 25 mM | 0.1881 mL | 0.9405 mL | 1.8810 mL | 4.7026 mL | |
| 30 mM | 0.1568 mL | 0.7838 mL | 1.5675 mL | 3.9188 mL | |
| 40 mM | 0.1176 mL | 0.5878 mL | 1.1756 mL | 2.9391 mL | |
| 50 mM | 0.0941 mL | 0.4703 mL | 0.9405 mL | 2.3513 mL | |
| 60 mM | 0.0784 mL | 0.3919 mL | 0.7838 mL | 1.9594 mL | |
| 80 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4696 mL | |
| 100 mM | 0.0470 mL | 0.2351 mL | 0.4703 mL | 1.1756 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Arginine-15N2 hydrochloride Related Classifications
HY-N0455AS Related Classifications
Powered by Bioz