Etrasimod arginine
Based on 1 publication(s) in Google Scholar
Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.86%
- CAS 番号: 1206123-97-8
- 分子式: C32H40F3N5O5
- 分子量:631.69
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Etrasimod arginine
More
生物活性
製品説明
IC50 & Target
As a full agonist of recombinant human (6.1 nM EC50), mouse (3.65 nM EC50), dog (4.19 nM EC50), and monkey (8.7 nM EC50) S1P1 receptors[1]
As a partial agonist of human S1P4 (147 nM EC50) and S1P5 (24.4 nM EC50)[1]
化学情報
-
CAS 番号 1206123-97-8
-
性状 Solid
-
分子量 631.69
-
分子式 C32H40F3N5O5
-
Color White to off-white
-
SMILES
N[C@@H](CCCNC(N)=N)C(O)=O.O=C(O)C[C@H]1CCC2=C1NC3=C2C=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C3
-
別名
APD334 arginine
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Heliyon
Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling. [Abstract]2024 Jul 4;10(13):e34066. PMID: 39071639
溶剤 & 溶解度
体外:
DMSO : 35 mg/mL (55.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (276 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5831 mL | 7.9153 mL | 15.8305 mL | 39.5764 mL |
| 5 mM | 0.3166 mL | 1.5831 mL | 3.1661 mL | 7.9153 mL | |
| 10 mM | 0.1583 mL | 0.7915 mL | 1.5831 mL | 3.9576 mL | |
| 15 mM | 0.1055 mL | 0.5277 mL | 1.0554 mL | 2.6384 mL | |
| 20 mM | 0.0792 mL | 0.3958 mL | 0.7915 mL | 1.9788 mL | |
| 25 mM | 0.0633 mL | 0.3166 mL | 0.6332 mL | 1.5831 mL | |
| 30 mM | 0.0528 mL | 0.2638 mL | 0.5277 mL | 1.3192 mL | |
| 40 mM | 0.0396 mL | 0.1979 mL | 0.3958 mL | 0.9894 mL | |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7915 mL |
Etrasimod arginine 関連分類
HY-135432 関連分類
Powered by Bioz