2. GPCR/G Protein
  3. LPL Receptor
  4. Etrasimod arginine

Etrasimod arginine  (Synonyms: APD334 arginine)

Cat. No.: HY-135432 Purity: 99.86%
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Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model.

For research use only. We do not sell to patients.

Etrasimod arginine

Etrasimod arginine Chemical Structure

CAS No. : 1206123-97-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Etrasimod arginine:

Etrasimod arginine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Etrasimod arginine

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model[1].

IC50 & Target

As a full agonist of recombinant human (6.1 nM EC50), mouse (3.65 nM EC50), dog (4.19 nM EC50), and monkey (8.7 nM EC50) S1P1 receptors[1]
As a partial agonist of human S1P4 (147 nM EC50) and S1P5 (24.4 nM EC50)[1]
Molecular Weight

631.69

Formula

C32H40F3N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCCNC(N)=N)C(O)=O.O=C(O)C[C@H]1CCC2=C1NC3=C2C=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (55.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5831 mL 7.9153 mL 15.8305 mL
5 mM 0.3166 mL 1.5831 mL 3.1661 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5831 mL 7.9153 mL 15.8305 mL 39.5764 mL
5 mM 0.3166 mL 1.5831 mL 3.1661 mL 7.9153 mL
10 mM 0.1583 mL 0.7915 mL 1.5831 mL 3.9576 mL
15 mM 0.1055 mL 0.5277 mL 1.0554 mL 2.6384 mL
20 mM 0.0792 mL 0.3958 mL 0.7915 mL 1.9788 mL
25 mM 0.0633 mL 0.3166 mL 0.6332 mL 1.5831 mL
30 mM 0.0528 mL 0.2638 mL 0.5277 mL 1.3192 mL
40 mM 0.0396 mL 0.1979 mL 0.3958 mL 0.9894 mL
50 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7915 mL
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Etrasimod arginine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etrasimod1206123-97-8APD334APD 334APD-334LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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