Etrasimod arginine
Based on 1 publication(s) in Google Scholar
Etrasimod arginine is an orally available S1P receptor modulator that is a potent full agonist of the S1P1 receptor and has partial agonist activity at S1P4. Etrasimod arginine reduces inflammation in a CD4+CD45RBhigh T cell-transferred mouse colitis model.
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- Pureté : 99.86%
- CAS No.: 1206123-97-8
- Formule: C32H40F3N5O5
- Masse moléculaire:631.69
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Etrasimod arginine
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Activité biologique
Description
IC50 & Target
As a full agonist of recombinant human (6.1 nM EC50), mouse (3.65 nM EC50), dog (4.19 nM EC50), and monkey (8.7 nM EC50) S1P1 receptors[1]
As a partial agonist of human S1P4 (147 nM EC50) and S1P5 (24.4 nM EC50)[1]
Chemical Information
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CAS No. 1206123-97-8
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Appearance Solid
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Masse moléculaire 631.69
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Formule C32H40F3N5O5
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Color White to off-white
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SMILES
N[C@@H](CCCNC(N)=N)C(O)=O.O=C(O)C[C@H]1CCC2=C1NC3=C2C=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C3
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Synonyms
APD334 arginine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Heliyon
Development and validation of stability-indicating method of etrasimod by HPLC/DAD/MS/MS technique with greenness profiling. [Abstract]2024 Jul 4;10(13):e34066. PMID: 39071639
Solvant et solubilité
In Vitro:
DMSO : 35 mg/mL (55.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5831 mL | 7.9153 mL | 15.8305 mL | 39.5764 mL |
| 5 mM | 0.3166 mL | 1.5831 mL | 3.1661 mL | 7.9153 mL | |
| 10 mM | 0.1583 mL | 0.7915 mL | 1.5831 mL | 3.9576 mL | |
| 15 mM | 0.1055 mL | 0.5277 mL | 1.0554 mL | 2.6384 mL | |
| 20 mM | 0.0792 mL | 0.3958 mL | 0.7915 mL | 1.9788 mL | |
| 25 mM | 0.0633 mL | 0.3166 mL | 0.6332 mL | 1.5831 mL | |
| 30 mM | 0.0528 mL | 0.2638 mL | 0.5277 mL | 1.3192 mL | |
| 40 mM | 0.0396 mL | 0.1979 mL | 0.3958 mL | 0.9894 mL | |
| 50 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7915 mL |
Etrasimod arginine Related Classifications
HY-135432 Related Classifications
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