FGFR-IN-19
Based on 1 publication(s) in Google Scholar
Arg-IN-1 is a selective Arginine (Arg)-targeting covalent inhibitor with IC50s of 9.7 nM and 30.4 nM for FGFR2 and FGFR3,respectively. Arg-IN-1 has the potential to avoid FGFR1/4-targeted toxicity as well as conquer acquired on-target resistance, potential for FGFR-targeting cancer therapy.
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- 화학식: C36H42N12O6
- 분자량:738.80
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) FGFR-IN-19
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Biological Activity
제품 설명
IC50 & Target
[1]|
FGFR2 9.7 nM (IC50) |
FGFR3 30.4 nM (IC50) |
FGFR1 2367.6 nM (IC50) |
FGFR4 7418.4 nM (IC50) |
In Vitro
Arg-IN-1 (Compound RF3) has excellent selectivity for FGFR2 and FGFR3 with 244-fold and 765-fold lower inhibition of FGFR1 and FGFR4, respectively[1].
Arg-IN-1 has superior anti-resistance activity with IC50 of 9.4 nM against the FGFR2 V564F mutation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 738.80
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화학식 C36H42N12O6
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SMILES
COCCNC1=NC(NC2=NNC(C3=CC=CC=C3)=C2)=NC(NC4CC5(C4)CCN(CC5)C(CN6C=C(N=N6)COC7=CC=C(C=C7)C(C(O)O)=O)=O)=N1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Microbiol
Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor. [Abstract]2022 Jul 18:13:934786. PMID: 35923391
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGFR-IN-19 Related Classifications
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