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Antiulcer activity

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45

Inhibitors & Agonists

1

Peptides

13

Natural
Products

7

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17507
    Pantoprazole
    4 Publications Verification

    BY1023; SKF96022

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole
  • HY-N2551
    Vitamin U chloride

    S-Methylmethionine sulfonium chloride

    		 Others Inflammation/Immunology
    Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration .
    Vitamin U chloride
  • HY-B0729
    Polaprezinc
    1 Publications Verification

    Zinc L-carnosine

    		 Biochemical Assay Reagents Inflammation/Immunology Cancer
    Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
    Polaprezinc
  • HY-123026
    Salannin

    		Bacterial Infection
    Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .
    Salannin
  • HY-17507B
    Pantoprazole sodium hydrate
    4 Publications Verification

    BY1023 sodium hydrate; SKF96022 sodium hydrate

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium hydrate
  • HY-17507A
    Pantoprazole sodium
    4 Publications Verification

    BY1023 sodium; SKF96022 sodium

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium
  • HY-N0165
    Methyl-Hesperidin

    		HIV Reverse Transcriptase Cardiovascular Disease Infection Inflammation/Immunology
    Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .
    Methyl-Hesperidin
  • HY-P4053
    Dalargin

    		Opioid Receptor Neurological Disease
    Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin (HY-A0276A)-induced kidney injury. Dalargin shows antiulcer activity .
    Dalargin
  • HY-W013331
    Deoxyartemisinin
    1 Publications Verification

    2-Deoxyartemisinin

    		 TNF Receptor Neurological Disease Inflammation/Immunology
    Deoxyartemisinin (2-Deoxyartemisinin) is an orally active anti-inflammatory and analgesic agent. Deoxyartemisinin selectively reduces the level of the pro-inflammatory cytokine TNF-α. Deoxyartemisinin alleviates neuropathic pain, inflammatory pain, and croton oil-induced ear edema.\nDeoxyartemisinin exerts an analgesic effect against thermal stimulation. Deoxyartemisinin has anti-ulcer activity. Deoxyartemisinin can be used in research related to inflammatory diseases, pain, and gastric ulcers .
    Deoxyartemisinin
  • HY-N7031
    (±)​-​Vasicine

    (±)​-Peganine

    		 Proton Pump Inflammation/Immunology
    (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H +-K +-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .
    (±)​-​Vasicine
  • HY-N4233
    Bisabolangelone

    		p38 MAPK Inflammation/Immunology
    Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities .
    Bisabolangelone
  • HY-17507AR
    Pantoprazole sodium (Standard)

    BY1023 sodium (Standard); SKF96022 sodium (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium (Standard)
  • HY-127072
    Amicoumacin A

    		Antibiotic Bacterial Infection Inflammation/Immunology Cancer
    Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers [2] .
    Amicoumacin A
  • HY-N3356
    Lupeol palmitate

    		Others Metabolic Disease
    Lupeol palmitate is a natural compound with antiulcer activities. Lupeol palmitate has a gastroprotective action .
    Lupeol palmitate
  • HY-W391625
    (Rac)-Dehydrocostus Lactone

    (Rac)-Epiligulyl oxide

    		 Fungal Cancer
    (Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
    (Rac)-Dehydrocostus Lactone
  • HY-N4328
    Pasakbumin B

    13α-(21)-Epoxyeurycomanone

    		 Others Inflammation/Immunology
    Pasakbumin B, a bioactive compound from Eurycoma longifolia Jack, exhibits potent antiulcer activity .
    Pasakbumin B
  • HY-128695
    Oleanolic acid hemiphthalate disodium salt

    		Drug Derivative Inflammation/Immunology
    Oleanolic acid hemiphthalate disodium salt is a hemiphthalate derivative of Oleanolic acid (HY-128695) with anti-inflammatory and potential anti-ulcer activities .
    Oleanolic acid hemiphthalate disodium salt
  • HY-W011334
    Methyl 12-oxooctadecanoate

    		Drug Derivative Metabolic Disease
    Methyl 12-oxooctadecanoate is a fatty acid that can be isolated from the pulp of Livistona decipiens (Palmae), which has anti-hyperlipidemic and anti-ulcer activities .
    Methyl 12-oxooctadecanoate
  • HY-106347
    Itriglumide

    CR 2945

    		 Cholecystokinin Receptor Inflammation/Immunology
    Itriglumide (CR 2945) is an anthranilic acid derivative. Itriglumide is a potent and selective CCKB receptor antagonist, with an IC50 of 2.3 nM. Itriglumide antagonizes the response to gastrin in a dose-dependent manner with an IC50 of 5.9 nM. Itriglumide shows antisecretory and antiulcer activity .
    Itriglumide
  • HY-B0779A
    (5E,9E,13E)-Teprenone

    (5E,9E,13E)-Geranylgeranylacetone

    		 HSP Metabolic Disease
    (5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress .
    (5E,9E,13E)-Teprenone
  • HY-17507S
    Pantoprazole-d6

    BY1023-d6; SKF96022-d6

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Inflammation/Immunology Cancer
    Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d6
  • HY-117783
    Y-05460M-A

    		Antibiotic Infection
    Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .
    Y-05460M-A
  • HY-17507R
    Pantoprazole (Standard)

    BY1023 (Standard); SKF96022 (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole (Standard)
  • HY-17507BR
    Pantoprazole sodium hydrate (Standard)

    BY1023 sodium hydrate (Standard); SKF96022 sodium hydrate (Standard)

    		 Reference Standards Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (sodium hydrate) (Standard) is the analytical standard of Pantoprazole (sodium hydrate). This product is intended for research and analytical applications. Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium hydrate (Standard)
  • HY-129424
    Mezolidon

    KM-1146

    		 Others Inflammation/Immunology
    Mezolidon (KM-1146) is a compound with anti-ulcer activity, which exerts its anti-ulcer activity by enhancing the defense ability of gastric mucosa, especially by increasing and maintaining gastric mucosal blood flow and protecting gastric mucosal potential difference. Mezolidon can be used for the study of gastric mucosal protection .
    Mezolidon
  • HY-114966
    RP73870

    		Cholecystokinin Receptor Inflammation/Immunology
    RP73870 is an orally active gastrin/cholecystokinin-B receptor antagonist. RP73870 inhibits basal gastric acid secretion in the rat. RP73870 has potent anti-ulcer activity .
    RP73870
  • HY-167141
    AY 29315

    		Histamine Receptor Inflammation/Immunology
    AY 29315 is a selective and orally active histamine H2-receptor antagonist. AY 29315 can inhibit astric acid secretion and shows antiulcer activity. AY 29315 can be used for the research of gastric ulcer .
    AY 29315
  • HY-N7031R
    (±)-Vasicine (Standard)

    (±)​-Peganine (Standard)

    		 Reference Standards Proton Pump Inflammation/Immunology
    (±)-Vasicine (Standard) is the analytical standard of (±)-Vasicine (HY-N7031). This product is intended for research and analytical applications. (±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine) significantly inhibits H+-K+-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect .
    (±)-Vasicine (Standard)
  • HY-120381
    PD 136450

    CAM 1189

    		 Cholecystokinin Receptor Neurological Disease Inflammation/Immunology
    PD 136450 (CAM 1189) is an antagonist for cholecystokinin 2 (CCK2). PD 136450 exhibits anti-secretory, anxiolytic and anti-ulcer activities, inhibits gastric acid secretion (IC50=1 mg/kg), and ameliorates the haemorrhagic lesions (IC50=4.7 mg/kg) in rats .
    PD 136450
  • HY-158995S
    3-Epiglycyrrhetinic acid-d2

    3α-Glycyrrhetic acid-d2

    		 Isotope-Labeled Compounds Others
    3-Epiglycyrrhetinic acid-d2 (3α-Glycyrrhetic acid-d2) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
    3-Epiglycyrrhetinic acid-d2
  • HY-158995S1
    3-Epiglycyrrhetinic acid-d3

    3α-Glycyrrhetic acid-d3

    		 Isotope-Labeled Compounds Others
    3-Epiglycyrrhetinic acid-d3 (3α-Glycyrrhetic acid-d3) is the deuterium-labeled 3-Epiglycyrrhetinic acid. 3-Epiglycyrrhetinic acid is a derivative of glycyrrhetic acid. Glycyrrhetic acid and its derivative are considered to have anti-inflammatory, anti-ulcer, and antiviral activities .
    3-Epiglycyrrhetinic acid-d3
  • HY-119762
    Spizofurone

    AG-629

    		 Prostaglandin Receptor Cardiovascular Disease
    Spizofurone is an anti-ulcer compound with increased gastric mucosal blood flow activity and oral activity. Spizofurone has a similar mechanism of action to PGE2 (HY-101952), Spizofurone is capable of acting through local and systemic pathways and may promote ulcer healing by improving blood supply to the gastric mucosa. Spizofurone can be used to study the development strategy of gastric ulcer .
    Spizofurone
  • HY-170586
    JAK05

    		Bacterial Na+/K+ ATPase COX TNF Receptor Prostaglandin Receptor Infection Inflammation/Immunology
    JAK05 exhibits inhibitory activity against Helicobacter pylori, inhibits strains J63, J196 and J107 with MIC of 3-5 µg/mL. JAK05 exhibits binding affinity to H+/K+-ATPase, COX-1/2, TNF-α and PGE2, reveals antioxidant and anti-inflammatory activities. JAK05 exhibits anti-ulcer activity in rat ethanol-induced gastric ulcer models .
    JAK05
  • HY-N13167
    3-Keto-tirucall-8,24-dien-21-oic acid

    		Reactive Oxygen Species (ROS) Inflammation/Immunology Cancer
    3-Keto-tirucall-8,24-dien-21-oic acid is a tetracyclic triterpene compound that can be isolated from frankincense. 3-Keto-tirucall-8,24-dien-21-oic acid has activities like anti-inflammatory, anti-tumor, anti-ulcer, memory improvement, and antioxidant properties .
    3-Keto-tirucall-8,24-dien-21-oic acid
  • HY-17507S1
    Pantoprazole-d3

    BY1023-d3; SKF96022-d3

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Inflammation/Immunology Cancer
    Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d3
  • HY-W739793
    Pantoprazole-d8 sodium

    BY1023-d8 sodium; SKF96022-d8 sodium

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole-d8 (BY1023-d8) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d8 sodium
  • HY-17507S4
    Pantoprazole-d4

    BY1023-d4; SKF96022-d4

    		 Isotope-Labeled Compounds Inflammation/Immunology Cancer
    Pantoprazole-d4 (BY1023-d4) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d4
  • HY-17507S2
    Pantoprazole-d8

    BY1023-d8; SKF96022-d8

    		 Isotope-Labeled Compounds Bacterial Autophagy Apoptosis Proton Pump Inflammation/Immunology Cancer
    Pantoprazole-d8 (BY1023-d8) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d8
  • HY-171448
    SU-740

    		Others Inflammation/Immunology
    SU-740 is a chalcone derivative with anti-ulcer activity .
    SU-740
  • HY-121665
    Rosaprostol

    		Others Others
    Rosaprostol is a compound with antiulcer activity, and its enantiomers can be synthesized from the corresponding building blocks via a specific synthetic route involving multistep reactions and stereoselective transformations.
    Rosaprostol
  • HY-169223
    Roxatidine hydrochloride

    		Endogenous Metabolite Endocrinology
    Roxatidine hydrochloride is an anti-ulcer compound with the activity of inhibiting gastric acid secretion. Roxatidine hydrochloride effectively inhibits duodenal and gastric ulcers and reduces ulcer pain. Roxatidine hydrochloride has a better safety profile than other similar compounds due to the lower dose required for effective inhibition .
    Roxatidine hydrochloride
  • HY-400142
    (E)-4-(2-Nitrophenyl)-4-oxobut-2-enoic acid

    		Drug Intermediate Inflammation/Immunology
    (E)-4-(2-Nitrophenyl)-4-oxobut-2-enoic acid is an intermediate that can be used to synthesize Phenyl-4-oxo-2-butenoic acid. Phenyl-4-oxo-2-butenoic acid has high antiulcer and antisecretory activities .
    (E)-4-(2-Nitrophenyl)-4-oxobut-2-enoic acid
  • HY-N15354
    Jujubasaponin IV

    		Others Others
    Jujubasaponin IV is a triterpenoid saponin compound found in Zizyphi Fructus. Animal studies have shown that Jujubasaponin IV possesses certain anti-ulcer activity, possibly through mechanisms such as enhancing the gastric mucosal barrier or inhibiting gastric acid secretion. Jujubasaponin IV can be used in research on digestive system diseases, particularly in the study of gastric ulcer mechanisms .
    Jujubasaponin IV
  • HY-181038
    Rifabutin-vonoprazan conjugate 1

    		Bacterial Infection
    Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer .
    Rifabutin-vonoprazan conjugate 1
  • HY-N0165R
    Methyl-Hesperidin (Standard)

    		Reference Standards HIV Reverse Transcriptase Cardiovascular Disease Infection Inflammation/Immunology
    Methyl-Hesperidin (Standard) is the analytical standard of Methyl-Hesperidin (HY-N0165). This product is intended for research and analytical applications. Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs .
    Methyl-Hesperidin (Standard)

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