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Vitamin U chloride  (Synonyms: S-Methylmethionine sulfonium chloride)

Cat. No.: HY-N2551 Purity: ≥95.0%
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Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration.

For research use only. We do not sell to patients.

Vitamin U chloride Chemical Structure

Vitamin U chloride Chemical Structure

CAS No. : 1115-84-0

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10 mg USD 30 In-stock
25 mg USD 60 In-stock
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Based on 1 publication(s) in Google Scholar

Vitamin U chloride Related Antibodies

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Description

Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5].

In Vitro

Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1].
Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1].
Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2].
Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vitamin U chloride Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human dermal fibroblasts(hDFs)
Concentration: 100 μM
Incubation Time: 24 h
Result: Promoted hDFs proliferation.

Western Blot Analysis[3]

Cell Line: 3T3-L1 cells
Concentration: 50, 70, 90 mM
Incubation Time: 7 days
Result: Increased AMPK phosphorylation and decreased PPAR-γ levels.
In Vivo

Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats[4].
Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Valproic acid (VPA)-induced rats with liver damage[4]
Dosage: 50 mg/kg
Administration: Oral gavage
Result: Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities.
Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c.
Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes.
Molecular Weight

199.70

Formula

C6H14ClNO2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[S+](C)CC[C@H](N)C(O)=O.[Cl-]
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (500.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0075 mL 25.0376 mL 50.0751 mL
5 mM 1.0015 mL 5.0075 mL 10.0150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0075 mL 25.0376 mL 50.0751 mL 125.1878 mL
5 mM 1.0015 mL 5.0075 mL 10.0150 mL 25.0376 mL
10 mM 0.5008 mL 2.5038 mL 5.0075 mL 12.5188 mL
15 mM 0.3338 mL 1.6692 mL 3.3383 mL 8.3459 mL
20 mM 0.2504 mL 1.2519 mL 2.5038 mL 6.2594 mL
25 mM 0.2003 mL 1.0015 mL 2.0030 mL 5.0075 mL
30 mM 0.1669 mL 0.8346 mL 1.6692 mL 4.1729 mL
40 mM 0.1252 mL 0.6259 mL 1.2519 mL 3.1297 mL
50 mM 0.1002 mL 0.5008 mL 1.0015 mL 2.5038 mL
60 mM 0.0835 mL 0.4173 mL 0.8346 mL 2.0865 mL
80 mM 0.0626 mL 0.3130 mL 0.6259 mL 1.5648 mL
100 mM 0.0501 mL 0.2504 mL 0.5008 mL 1.2519 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vitamin U1115-84-0S-Methylmethionine sulfoniumOthersSkinwoundulcerationfibroblaststomachulcers3T3-L1oxidative stresshepatotoxicityInhibitorinhibitorinhibit

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