Vitamin U chloride
Based on 1 Customer Validation
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 1115-84-0
- Formula: C6H14ClNO2S
- Molecular Weight:199.70
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1].
Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1].
Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2].
Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human dermal fibroblasts(hDFs)
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Concentration:100 μM
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Incubation Time:24 h
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Result:Promoted hDFs proliferation.
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Cell Line:3T3-L1 cells
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Concentration:50, 70, 90 mM
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Incubation Time:7 days
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Result:Increased AMPK phosphorylation and decreased PPAR-γ levels.
Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Valproic acid (VPA)-induced rats with liver damage[4]
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Dosage:50 mg/kg
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Administration:Oral gavage
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Result:Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities.
Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c.
Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes.
Chemical Information
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CAS No. 1115-84-0
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Appearance Solid
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Molecular Weight 199.70
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Formula C6H14ClNO2S
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Color Off-white to light yellow
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SMILES
C[S+](C)CC[C@H](N)C(O)=O.[Cl-]
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Synonyms
S-Methylmethionine sulfonium chloride
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 100 mg/mL (500.75 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Won-Serk Kim, et al. Accelerated wound healing by S-methylmethionine sulfonium: evidence of dermal fibroblast activation via the ERK1/2 pathway. Pharmacology. 2010;85(2):68-76. [Content Brief]
[2]. Ilona Rácz, et al. S-methylmethionine reduces cell membrane damage in higher plants exposed to low-temperature stress. J Plant Physiol. 2008 Sep 29;165(14):1483-90. [Content Brief]
[3]. Na Young Lee, et al. Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines. Ann Dermatol. 2012 Feb;24(1):39-44. [Content Brief]
[4]. Ertan Celik, et al. Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis. Toxicol Mech Methods. 2021 Oct;31(8):600-608. [Content Brief]
[5]. Dileknur Topaloglu, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. J Biochem Mol Toxicol. 2022 Sep;36(9):e23124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 5.0075 mL | 25.0376 mL | 50.0751 mL | 125.1878 mL |
| 5 mM | 1.0015 mL | 5.0075 mL | 10.0150 mL | 25.0376 mL | |
| 10 mM | 0.5008 mL | 2.5038 mL | 5.0075 mL | 12.5188 mL | |
| 15 mM | 0.3338 mL | 1.6692 mL | 3.3383 mL | 8.3459 mL | |
| 20 mM | 0.2504 mL | 1.2519 mL | 2.5038 mL | 6.2594 mL | |
| 25 mM | 0.2003 mL | 1.0015 mL | 2.0030 mL | 5.0075 mL | |
| 30 mM | 0.1669 mL | 0.8346 mL | 1.6692 mL | 4.1729 mL | |
| 40 mM | 0.1252 mL | 0.6259 mL | 1.2519 mL | 3.1297 mL | |
| 50 mM | 0.1002 mL | 0.5008 mL | 1.0015 mL | 2.5038 mL | |
| 60 mM | 0.0835 mL | 0.4173 mL | 0.8346 mL | 2.0865 mL | |
| 80 mM | 0.0626 mL | 0.3130 mL | 0.6259 mL | 1.5648 mL | |
| 100 mM | 0.0501 mL | 0.2504 mL | 0.5008 mL | 1.2519 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Vitamin U chloride Related Classifications
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