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Benzimidazoles

" in MedChemExpress (MCE) Product Catalog:

65

Inhibitors & Agonists

1

Biochemical Assay Reagents

12

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-133694
    2-Aminoflubendazole

    		Drug Metabolite Others
    2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes .
    2-Aminoflubendazole
  • HY-17623C
    (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

    		 Proton Pump Metabolic Disease
    (R)-Tegoprazan (example 3), a benzimidazole derivative, is a potent kidney H +/K +-ATPase inhibitor with an IC50 of 98 nM of canine kidney Na +/K +-ATPase. (R)-Tegoprazan has the potential for gastrointestinal diseases research .
    (R)-Tegoprazan
  • HY-W011239
    Fenbendazole sulfone

    Oxfendazole sulfone; FBZ-SO2

    		 Parasite Infection
    Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .
    Fenbendazole sulfone
  • HY-112191
    PI3K-IN-10

    		PI3K Cancer
    PI3K-IN-10 is a potent pan-PI3K inhibitor as a benzimidazole derivative, compound 332, extracted from patent WO2018057808A1 .
    PI3K-IN-10
  • HY-152135
    TJ08

    		Apoptosis Cancer
    TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent .
    TJ08
  • HY-106098
    Adibendan

    BM 14478

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent .
    Adibendan
  • HY-108411
    Emedastine

    		Histamine Receptor Inflammation/Immunology
    Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .
    Emedastine
  • HY-B2178
    Emedastine difumarate

    		Histamine Receptor Inflammation/Immunology
    Emedastine difumarate is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine difumarate is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .
    Emedastine difumarate
  • HY-156635
    TIE-2/VEGFR-2 kinase-IN-3

    		Tie VEGFR Cardiovascular Disease
    TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis .
    TIE-2/VEGFR-2 kinase-IN-3
  • HY-156637
    TIE-2/VEGFR-2 kinase-IN-4

    		Tie VEGFR Cardiovascular Disease
    TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis .
    TIE-2/VEGFR-2 kinase-IN-4
  • HY-13582
    Carbendazim
    4 Publications Verification

    		 Fungal Parasite Infection Cancer
    Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina . Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma .
    Carbendazim
  • HY-149919
    Antimalarial agent 23

    		Parasite Infection
    Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin .
    Antimalarial agent 23
  • HY-152158
    α-Glucosidase-IN-22

    		Glucosidase Metabolic Disease
    α-Glucosidase-IN-22 (compound 7i), a benzimidazole, is a potent α-glucosidase inhibitor with an IC50 of 0.64 μM. α-Glucosidase-IN-22 is a potent anti-diabetic agent and has the potential for type 2 diabetes mellitus (T2DM) research .
    α-Glucosidase-IN-22
  • HY-133859
    M084

    		Mitochondrial Metabolism Metabolic Disease
    M084 is a benzimidazole derivative. M084 inhibits the mitochondrial respiration, activate mitochondrial unfolded protein response and AMPK, recruites SIR-2.1 and SKN-1, and finally through the transcription factor DAF-16, delays the aging process of C. elegans .
    M084
  • HY-144718
    PTP1B-IN-17

    		Phosphatase Metabolic Disease
    PTP1B-IN-17 (Compound 45), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 30.2 μM. PTP1B-IN-17 can be used for the research of type 2 diabetes.
    PTP1B-IN-17
  • HY-144716
    PTP1B-IN-19

    		Phosphatase Metabolic Disease
    PTP1B-IN-19 (Compound 43), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 23.3 μM. PTP1B-IN-19 can be used for the research of type 2 diabetes.
    PTP1B-IN-19
  • HY-144713
    PTP1B-IN-16

    		Phosphatase Metabolic Disease
    PTP1B-IN-16 (Compound 46), a potential selective benzimidazole derivative, acts as a protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 12.6 μM. PTP1B-IN-16 can be used for the research of type 2 diabetes.
    PTP1B-IN-16
  • HY-153626
    Chlamydia pneumoniae-IN-1

    		Bacterial Antibiotic Infection Inflammation/Immunology
    Chlamydia pneumoniae-IN-1 (compound 55), a benzimidazole, shows high activity against the bacterium. Chlamydia pneumoniae-IN-1 has 99% inhibition of C. pneumoniae Growth at 10 μM, and has 95% inhibition effect on the viability of the host cells at 10 μM. Chlamydia pneumoniae-IN-1 inhibits the growth of the CV-6 strain with a MIC of 12.6 μM. Chlamydia pneumoniae-IN-1 has antichlamydial efficiency .
    Chlamydia pneumoniae-IN-1
  • HY-123305S
    5-Hydroxymebendazole-d3

    		Parasite Isotope-Labeled Compounds Others
    5-Hydroxymebendazole-d3 is a deuterium labeled 5-Hydroxymebendazole. 5-Hydroxymebendazole is the one metabolite of Benzimidazoles[1].
    5-Hydroxymebendazole-d3
  • HY-123305
    5-Hydroxymebendazole

    		Parasite Others
    5-Hydroxymebendazole is the one metabolite of Benzimidazoles. Benzimidazoles are safe, broad-spectrum anthelmintic agents and are widely used for prevention and treatment of parasitic infections in food-producing animals .
    5-Hydroxymebendazole
  • HY-111662
    Fc 11a-2

    		NOD-like Receptor (NLR) Inflammation/Immunology
    Fc 11a-2, a benzimidazole compound, is an orally active and potent NLRP3 inflammasome inhibitor. Fc 11a-2 restrains the formation of NLRP3 inflammasome by inhibiting activation of caspase-1 and thus the activation of IL-1b/IL-18. Fc 11a-2 prevents the development of Dextran sulfate sodium (DSS; HY-116282C)-induced murine experimental colitis .
    Fc 11a-2
  • HY-133694S
    2-Aminoflubendazole-13C6

    		Isotope-Labeled Compounds Drug Metabolite Others
    2-Aminoflubendazole- 13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole-13C6
  • HY-W140203
    2-(2′-Hydroxyphenyl)benzimidazole

    		Fluorescent Dye Others
    2-(2′-Hydroxyphenyl)benzimidazole is some of the most extensively studied excited state intramolecular proton transfer (ESIPT) molecules exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl)benzimidazole has been applied as a fluorescent probe in various systems .
    2-(2′-Hydroxyphenyl)<em>benzimidazole</em>
  • HY-B0413
    Fenbendazole
    5 Publications Verification

    		 Parasite HIF/HIF Prolyl-Hydroxylase Microtubule/Tubulin Antibiotic Infection
    Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .
    Fenbendazole
  • HY-B0413S
    Fenbendazole-d3
    2 Publications Verification

    		 HIF/HIF Prolyl-Hydroxylase Parasite Microtubule/Tubulin Antibiotic Infection
    Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole-d3 is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].
    Fenbendazole-d3
  • HY-114750
    Mebendazole-amine

    		Drug Metabolite Others
    Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent .
    Mebendazole-amine
  • HY-103020
    BAY-1816032
    Maximum Cited Publications
    9 Publications Verification

    		 Others Cancer
    BAY-1816032 is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM.
    BAY-1816032
  • HY-13582S
    Carbendazim-d4

    		Isotope-Labeled Compounds Fungal Infection Cancer
    Carbendazim-d4 is the deuterium labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].
    Carbendazim-d4
  • HY-136384
    Diethofencarb

    		Fungal Infection
    Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical .
    Diethofencarb
  • HY-135410
    ABZ-amine

    Amino albendazole

    		 Drug Metabolite Infection
    ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations .
    ABZ-amine
  • HY-B0299
    Oxibendazole
    2 Publications Verification

    		 Parasite Apoptosis Infection
    Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities .
    Oxibendazole
  • HY-B0223S
    Albendazole-d3

    SKF-62979-d3

    		 Parasite Infection
    Albendazole-d3 is the deuterium labeled Albendazole, which is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations[1].
    Albendazole-d3
  • HY-W002064
    1H-Benzimidazole-6-carboxylic acid

    		Biochemical Assay Reagents Others
    1H-Benzimidazole-6-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    1H-<em>Benzimidazole</em>-6-carboxylic acid
  • HY-W008378
    5-Methoxy-2-benzimidazolethiol

    		Biochemical Assay Reagents Others
    5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied .
    5-Methoxy-2-benzimidazolethiol
  • HY-118282
    mPGES1-IN-7

    		PGE synthase Endocrinology
    mPGES-1-IN-2 (compound III) is a benzimidazole mPGES-1 inhibitor that reduces PGE2 production and tends to reduce levels of other prostaglandins.
    mPGES1-IN-7
  • HY-B0263
    Thiabendazole
    1 Publications Verification

    Tiabendazole; 2-(4-Thiazolyl)benzimidazole

    		 Mitochondrial Metabolism Parasite CDK MDM-2/p53 Others Caspase VEGFR Interleukin Related Infection Cardiovascular Disease Inflammation/Immunology Cancer
    Thiabendazole is an orally available benzimidazole fungicide with repellent and anticancer activities. Thiabendazole can result in developmental malformations. Thiabendazole can be used for modeling .
    Thiabendazole
  • HY-114750S
    Mebendazole-amine-13C6

    		Isotope-Labeled Compounds Drug Metabolite Others
    Mebendazole-amine- 13C6 is the 13C6 labeled Mebendazole-amine. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine-13C6
  • HY-B0299R
    Oxibendazole (Standard)

    		Parasite Apoptosis Infection
    Oxibendazole (Standard) is the analytical standard of Oxibendazole. This product is intended for research and analytical applications. Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities .
    Oxibendazole (Standard)
  • HY-146010
    Carbonic anhydrase inhibitor 13

    		Carbonic Anhydrase Cancer
    Carbonic anhydrase inhibitor 13 (compound 7) is a potent carbonic anhydrase (CA) inhibitor, which features 3-methylthiazolo[3,2-a]benzimidazole moiety (as a tail) connected to the zinc anchoring benzenesulfonamide moiety via ureido linker .
    Carbonic anhydrase inhibitor 13
  • HY-Y1250S4
    Fmoc-Gly-OH-1-13C

    		Fungal Infection Cancer
    Fmoc-Gly-OH-1- 13C is a 13C-labeled Carbendazim. Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria, Fusarium and Sclerotina[1][3]. Carbendazim is a
    Fmoc-Gly-OH-1-13C
  • HY-136557
    AFM32a

    PAD2-IN-1

    		 Protein Arginine Deiminase Inflammation/Immunology Cancer
    AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) .
    AFM32a
  • HY-136557A
    AFM32a hydrochloride
    1 Publications Verification

    PAD2-IN-1 hydrochloride

    		 Protein Arginine Deiminase Inflammation/Immunology Cancer
    AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold) .
    AFM32a hydrochloride
  • HY-156080
    PI3K-IN-48

    		PI3K Akt Cancer
    PI3K-IN-48 is a PI3K inhibitor with IC50 value of 1.55 ± 0.18 μM for A549 cells. PI3K-IN-48 can induce G0/G1 phase arrest, cell apoptosis, and down-regulate expression of p-PI3K and p-Akt. PI3K-IN-48 can be used for human lung cancers diseases research .
    PI3K-IN-48
  • HY-160261S
    EP300/CBP-IN-2

    		Epigenetic Reader Domain Cancer
    EP300/CBP-IN-2 is a potent EP300/CBP inhibitor that has good activity in vivo. EP300/CBP-IN-2 can be used for the research of cancer .
    EP300/CBP-IN-2
  • HY-110199
    TC-I 2014

    		TRP Channel Neurological Disease
    TC-I 2014 (compound 5) is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models .
    TC-I 2014
  • HY-W008378S
    5-Methoxy-2-benzimidazolethiol-d3

    		Isotope-Labeled Compounds Others
    5-Methoxy-2-benzimidazolethiol-d3 is the deuterium labeled 5-Methoxy-2-benzimidazolethiol[1]. 5-Methoxy-2-benzimidazolethiol is a benzimidazole. The iodimetric determination of 5-Methoxy-2-benzimidazolethiol in alkaline media is studied[2].
    5-Methoxy-2-benzimidazolethiol-d3
  • HY-108411S
    Emedastine-13C,d3 fumarate

    		Isotope-Labeled Compounds Histamine Receptor Inflammation/Immunology
    Emedastine- 13C,d3 (fumarate) is the 13C- and deuterium labeled Emedastine. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis[1][2][3].
    Emedastine-13C,d3 fumarate
  • HY-17507
    Pantoprazole
    3 Publications Verification

    BY1023; SKF96022

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole
  • HY-17507A
    Pantoprazole sodium
    3 Publications Verification

    BY1023 sodium; SKF96022 sodium

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium
  • HY-17507B
    Pantoprazole sodium hydrate
    3 Publications Verification

    BY1023 sodium hydrate; SKF96022 sodium hydrate

    		 Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole sodium hydrate

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