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Cat. No.: HY-156080

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PI3K-IN-48

PI3K-IN-48 is a PI3K inhibitor with IC₅₀ value of 1.55 ± 0.18 μM for A549 cells. PI3K-IN-48 can induce G0/G1 phase arrest, cell apoptosis, and down-regulate expression of p-PI3K and p-Akt. PI3K-IN-48 can be used for human lung cancers diseases research.

For research use only. We do not sell to patients.

CAS No.: 3052306-60-9
Formula: C₂₅H₂₁FN₂O₄
Molecular Weight:432.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PI3K-IN-48 Chemical Structure

CAS No.: 3052306-60-9

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Biological Activity
- Description
- Cellular Effect
Chemical Information
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Bioz

Biological Activity

Description

All PI3K Isoforms :

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.55 μM Compound: 4w	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
HCT-116	IC₅₀	1.68 μM Compound: 4w	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
HepG2	IC₅₀	88.66 μM Compound: 4w	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
L02	IC₅₀	41.45 μM Compound: 4w	Cytotoxicity against human L02 cells assessed as inhibition of cell growth by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
MCF7	IC₅₀	2.01 μM Compound: 4w	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
PC-3	IC₅₀	25.48 μM Compound: 4w	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]
SiHa	IC₅₀	9.36 μM Compound: 4w	Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human SiHa cells assessed as inhibition of cell growth by MTT assay	[PMID: 37689214]

Chemical Information

CAS No. 3052306-60-9
Molecular Weight 432.44
Formula C₂₅H₂₁FN₂O₄
SMILES

COC1=CC(OC)=C(C=C1C2=NC3=CC(OC)=C(C=C3N2)C#CC4=C(C=CC=C4)F)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu W, et al. Design, synthesis and antitumor effects of novel benzimidazole derivatives as PI3K inhibitors. Bioorg Med Chem Lett. 2023 Sep 7;95:129469. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PI3K-IN-48

All PI3K Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PI3K-IN-48 Related Classifications

HY-156080 Related Classifications