オキシベンダゾール
Based on 3 publication(s) in Google Scholar
Oxibendazole is an effective benzimidazole anthelmintic and is against nema-tode infections. Oxibendazole can induces apoptosis and has anti-cancer and anti-inflammation activities.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- CAS 番号: 20559-55-1
- 分子式: C12H15N3O3
- 分子量:249.27
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Oxibendazole
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生物活性
Cell proliferation decreased in both porcine trophectoder (pTr) and Porcine luminal epithelial (pLE) cells in response to Oxibendazole, and we determines that this is modulated through intracellular cell signal transduction. Phosphorylation of ERK1/2, P90RSK, and S6 are downregulated by exposure to a 200 nM dose of Oxibendazole in both types of cells, while the expression of phosphorylated JNK, AKT, and P70S6K is upregulated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 20559-55-1
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性状 Solid
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分子量 249.27
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分子式 C12H15N3O3
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Color White to yellow
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SMILES
O=C(OC)NC1=NC2=CC=C(OCCC)C=C2N1
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別名
Oxibendazole
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Commun Biol
Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. [Abstract]2024 Jan 24;7(1):123. PMID: 38267545 -
Molecules
2026 Mar 5;31(5):864. PMID: 41828851 -
溶剤 & 溶解度
DMSO : 5 mg/mL (20.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Hahyun Park , et al.Oxibendazole induces apoptotic cell death in proliferating porcine trophectoderm and uterine luminal epithelial cells via mitochondria-mediated calcium disruption and breakdown of mitochondrial membrane potential. Comp Biochem Physiol C Toxicol Pharmacol. 2019 Jun;220:9-19. [Content Brief]
[2]. Qiaoli Chen, et al. Oxibendazole inhibits prostate cancer cell growth. Oncol Lett. 2018 Feb;15(2):2218-2226. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0117 mL | 20.0586 mL | 40.1171 mL | 100.2929 mL |
| 5 mM | 0.8023 mL | 4.0117 mL | 8.0234 mL | 20.0586 mL | |
| 10 mM | 0.4012 mL | 2.0059 mL | 4.0117 mL | 10.0293 mL | |
| 15 mM | 0.2674 mL | 1.3372 mL | 2.6745 mL | 6.6862 mL | |
| 20 mM | 0.2006 mL | 1.0029 mL | 2.0059 mL | 5.0146 mL |
Oxibendazole 関連分類
HY-B0299 関連分類
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