TIE-2/VEGFR-2 kinase-IN-4
TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis.
For research use only. We do not sell to patients.
- CAS No.: 433224-29-4
- Formula: C26H17F4N5O4
- Molecular Weight:539.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
Description
IC50 & Target
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Tie2 5.2 mM (IC50) |
VEGFR-2 5.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
6.2 nM
Compound: 49
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Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA
Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA
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[PMID: 17676829] |
Chemical Information
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CAS No. 433224-29-4
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Molecular Weight 539.44
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Formula C26H17F4N5O4
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SMILES
O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C=C2)OC3=CC4=C(N=C(N4)NC(C5=CC=CO5)=O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TIE-2/VEGFR-2 kinase-IN-4 Related Classifications
HY-156637 Related Classifications
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