Tubulin polymerization-IN-50

Cat. No.: HY-155314: Data Sheet Handling Instructions
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Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC₅₀ of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase.

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Tubulin polymerization-IN-50 화학구조

CAS No. : 2998928-21-3

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

5.05 μM(SK-Mel-28 cells)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.84 μM Compound: 7n	Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
B16-F10	IC₅₀	3.1 μM Compound: 7n	Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
HCT-116	IC₅₀	6.98 μM Compound: 7n	Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
MCF7	IC₅₀	17.89 μM Compound: 7n	Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
NRK-52E	IC₅₀	53.82 μM Compound: 7n	Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
SK-MEL-28	IC₅₀	2.69 μM Compound: 7n	Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]

분자량

417.43

화학식

C₂₄H₂₀FN₃O₃

CAS No.

2998928-21-3

SMILES

COC1=CC(C2=NC3=C(N2)C=CC(F)=C3)=CC=C1OCC(N4CCC5=C4C=CC=C5)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Laxmikeshav K et al. Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies [published online ahead of print, 2023 Oct 3]. Bioorg Med Chem Lett. 2023;96:129494. [Content Brief]