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Cat. No.: HY-155314

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Tubulin polymerization-IN-50

Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC₅₀ of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase.

For research use only. We do not sell to patients.

CAS No.: 2998928-21-3
Formula: C₂₄H₂₀FN₃O₃
Molecular Weight:417.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Tubulin polymerization-IN-50 Chemical Structure

CAS No.: 2998928-21-3

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

5.05 μM(SK-Mel-28 cells)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.84 μM Compound: 7n	Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human A549 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
B16-F10	IC₅₀	3.1 μM Compound: 7n	Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against mouse B16-F10 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
HCT-116	IC₅₀	6.98 μM Compound: 7n	Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human HCT-116 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
MCF7	IC₅₀	17.89 μM Compound: 7n	Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human MCF7 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
NRK-52E	IC₅₀	53.82 μM Compound: 7n	Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Cytotoxicity against NRK-52E cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]
SK-MEL-28	IC₅₀	2.69 μM Compound: 7n	Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay Anticancer activity against human SK-MEL-28 cells assessed as inhibition in cell growth measured after 72 hrs by MTT assay	[PMID: 37797804]

Chemical Information

CAS No. 2998928-21-3
Molecular Weight 417.43
Formula C₂₄H₂₀FN₃O₃
SMILES

COC1=CC(C2=NC3=C(N2)C=CC(F)=C3)=CC=C1OCC(N4CCC5=C4C=CC=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Laxmikeshav K et al. Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies [published online ahead of print, 2023 Oct 3]. Bioorg Med Chem Lett. 2023;96:129494. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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