TJ08
TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent.
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- CAS No.: 2924274-19-9
- Formule: C22H16FN3O4
- Masse moléculaire:405.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
TJ08 (0-20 μM;48 and 72 h) has antiproliferative effect on various cancer cell lines with IC50s ranging from 1.88 to 3.82 μM[1].
TJ08 (1-10 μM; 24 h) instigates apoptosis by permuting mitochondrial membrane potential[1].
TJ08 (1-10 μM; 24 h) instigates S phase arrest and abrogates cancer cell progression[1].
TJ08 (1-10 μM; 24 h) causes the upregulation of cleaved caspase and downregulation of antiapoptotic BCl2 proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human leukemic cancer cells (Jurkat, K562, and Molt4), human cervical cancer cells (HeLa), human colorectal carcinoma cells (HCT116), and human pancreatic ductal adenocarcinoma (MIAPaCa-2)
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Concentration:0-20 μM
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Incubation Time:48 and 72 h
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Result:Showed effective against various cells with IC50s of 1.88 μM, 1.89 μM, 2.05 μM, 2.11 μM, 3.04 μM, and 3.82 μM against Jurkat, K562, MOLT-4, HeLa, HCT116, and MIA PaCa-2 cancer cell lines, respectively.
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Cell Line:Jurkat cells
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Concentration:1, 5, 10 μM
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Incubation Time:24 h
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Result:Induced cell death by apoptosis, not by necrosis, in a concentration-dependent manner.
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Cell Line:Jurkat cells
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Concentration:1, 5, 10 μM
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Incubation Time:24 h
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Result:Cauesd the accumulation of cells at the S phase in a concentration-dependent manner followed by increased accumulation of a sub-G1 population of cells.
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Cell Line:Jurkat cells
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Concentration:1, 5, 10 μM
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Incubation Time:24 h
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Result:Caused the upregulation of cleaved caspase and downregulation of antiapoptotic BCl2 proteins.
Chemical Information
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CAS No. 2924274-19-9
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Masse moléculaire 405.38
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Formule C22H16FN3O4
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SMILES
COC(C1=CC=C2C(N=C(N2CC3=CC=CC=C3)C4=CC=C(C([N+]([O-])=O)=C4)F)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TJ08 Related Classifications
HY-152135 Related Classifications
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