1. Epigenetics
  2. Protein Arginine Deiminase
  3. PAD2-IN-1 hydrochloride

PAD2-IN-1 hydrochloride 

Cat. No.: HY-136557A Purity: 99.71%
Handling Instructions

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

For research use only. We do not sell to patients.

PAD2-IN-1 hydrochloride Chemical Structure

PAD2-IN-1 hydrochloride Chemical Structure

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Description

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50 & Target

Protein Arginine Deiminase 2 (PAD2)[1]

In Vitro

In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) hydrochloride treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

517.00

Formula

C25H30ClFN6O3

SMILES

O=C(C1=CC=CC(CN2)=C1C2=O)N[[email protected]](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Product Name:
PAD2-IN-1 hydrochloride
Cat. No.:
HY-136557A
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