2988594-85-8
Chemical Structure
AFM32a hydrochloride
Synonym(s): PAD2-IN-1 hydrochloride
- CAS No.: 2988594-85-8
- Formula:C25H30ClFN6O3
- Molecular Weight:517.00
IUPAC Name: (S)-N-(1-(4-ethoxy-1-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-fluoroacetimidamido)butyl)-3-oxoisoindoline-4-carboxamide hydrochloride
InChIKey: PSVXWWOSYOYZKQ-LMOVPXPDSA-N
SMILES: O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl
Biological Activity: AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
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AFM32a hydrochloride | 99.37% | AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold). | ||||||||||||||||||||
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Keywords
