TIE-2/VEGFR-2 kinase-IN-3
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis.
For research use only. We do not sell to patients.
- CAS No.: 433224-09-0
- Formula: C23H17F4N5O3S
- Molecular Weight:519.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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Tie2 6.9 nM (IC50) |
VEGFR-2 3.5 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
76 nM
Compound: 34
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Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA
Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA
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[PMID: 17676829] |
Chemical Information
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CAS No. 433224-09-0
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Molecular Weight 519.47
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Formula C23H17F4N5O3S
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SMILES
O=C(NC1=NC2=C(N1)C=C(SC3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C=C2)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TIE-2/VEGFR-2 kinase-IN-3 Related Classifications
HY-156635 Related Classifications
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