1. Epigenetics
  2. Protein Arginine Deiminase
  3. PAD2-IN-1

PAD2-IN-1 

Cat. No.: HY-136557
Handling Instructions

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

For research use only. We do not sell to patients.

PAD2-IN-1 Chemical Structure

PAD2-IN-1 Chemical Structure

CAS No. : 2095109-82-1

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Description

PAD2-IN-1, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].

IC50 & Target

Protein Arginine Deiminase 2 (PAD2)[1]

In Vitro

In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells[1].
PAD2-IN-1 (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC 50 of 2.7 μM in HEK293T/PAD2 cells[1].

Molecular Weight

480.53

Formula

C₂₅H₂₉FN₆O₃

CAS No.

2095109-82-1

SMILES

O=C(C1=CC=CC(CN2)=C1C2=O)N[[email protected]](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PAD2-IN-1Protein Arginine DeiminasePeptidylarginine DeiminasePAD2benzimidazole-basedhistoneH3citrullinationtargetengagementInhibitorinhibitorinhibit

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