2095109-82-1
2095109-82-1
Chemical Structure
AFM32a
Synonym(s): PAD2-IN-1
- CAS No.: 2095109-82-1
- Formula:C25H29FN6O3
- Molecular Weight:480.53
IUPAC Name: (S)-N-(1-(4-ethoxy-1-methyl-1H-benzo[d]imidazol-2-yl)-4-(2-fluoroacetimidamido)butyl)-3-oxoisoindoline-4-carboxamide
InChIKey: AKTTZWGLDIDSGC-KRWDZBQOSA-N
SMILES: O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N
Biological Activity: AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold)[1].
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AFM32a | AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold). | |||||||||||||||||||||
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References
Keywords
