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Bifunctional Chelator

" in MedChemExpress (MCE) Product Catalog:

82

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54

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Click Chemistry

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GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99239
    Rosopatamab

    HUJ-591; TLX591

    		 PSMA Radionuclide-Drug Conjugates (RDCs) Cancer
    Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 ( 177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency .
    Rosopatamab
  • HY-159181
    p-NCS-Bz-DOTA-GA

    		Biochemical Assay Reagents Others
    p-NCS-Bz-DOTA-GA is a bifunctional chelator. p-NCS-Bz-DOTA-GA can be used as a versatile linker in targeted molecular imaging for both PET/SPECT and MRI applications .
    p-NCS-Bz-DOTA-GA
  • HY-156038
    (S)-p-SCN-Bn-DOTA

    		Biochemical Assay Reagents Others
    (S)-p-SCN-Bn-DOTA is a bifunctional chelator (BFC), a macrocyclic DOTA derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies .
    (S)-p-SCN-Bn-DOTA
  • HY-153552A
    NH2-UAMC1110 TFA

    		FAP Cancer
    NH2-UAMC1110 TFA is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 TFA is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose effect, and has been used in tumor diagnosis. NH2-UAMC1110 TFA structurally incorporates an active amino group, allowing it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.) to synthesize molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 TFA specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling-related processes. Its key activity is high targeting and high affinity, and its core function is to act as a targeting module coupled with bifunctional chelators (such as DOTA, DATA5m). NH2-UAMC1110 TFA can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
    NH2-UAMC1110 TFA
  • HY-W539916
    Azido-mono-amide-DOTA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.
    Azido-mono-amide-DOTA
  • HY-201263
    p-SCN-Bn-TCMC

    		Biochemical Assay Reagents Cancer
    p-SCN-Bn-TCMC is a bifunctional chelator. Its cyclen backbone binds Hg 2+, while its isothiocyanate group allows for conjugation to biomolecules. p-SCN-Bn-TCMC can be used in the research of prostate cancer .
    p-SCN-Bn-TCMC
  • HY-157977
    DOTA-GA-maleimide

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) MMP Cancer
    DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with 111In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling 111In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research .
    DOTA-GA-maleimide
  • HY-153552
    NH2-UAMC1110

    		FAP Cancer
    NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose-response, and has been used for tumor diagnosis. NH2-UAMC1110 introduces an active amino group into its structure, enabling it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.), thereby synthesizing molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling processes. Its key activity is high targeting and high affinity, and its core function is to be coupled with bifunctional chelators (such as DOTA, DATA5m) as a targeting module. NH2-UAMC1110 can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis .
    NH2-UAMC1110
  • HY-W749603
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
    Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
  • HY-100133A
    DOTA-ADIBO TFA

    		Integrin Cancer
    DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator (BFC) that allows drug conjugation via an uncatalyzed, copper-free cycloaddition reaction. DOTA-ADIBO TFA enables the construction of fusion chelator systems that can be further used to synthesize radiotracers after Cu[64] modification. Positron emission tomography imaging of tumors expressing integrin αvβ6 .
    DOTA-ADIBO TFA
  • HY-W678394
    DOTA-Thiol

    		Biochemical Assay Reagents Others
    DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.
    DOTA-Thiol
  • HY-W102590
    DOTMP

    		Biochemical Assay Reagents Others
    DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
    DOTMP
  • HY-48876
    p-NH2-Bn-DOTA

    		Biochemical Assay Reagents Others
    p-NH2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
    p-NH2-Bn-DOTA
  • HY-153551
    HBED-CC-tris(tert-butyl ester)

    		Biochemical Assay Reagents Cancer
    HBED-CC-tris(tert-butyl ester) is a derivative of HBED-CC and a bifunctional chelator. HBED-CC-tris(tert-butyl ester) can be used in the research of radiolabeling and compounds for tumor-assisted diagnosis .
    HBED-CC-tris(tert-butyl ester)
  • HY-W755033
    NH2-PEG4-DOTA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    NH2-PEG4-DOTA is a bifunctional DOTA chelator with one carboxyl group modified by NH2-PEG4, possessing both a metal-binding domain and a chemically reactive functional group. NH2-PEG4-DOTA can be used for time-resolved fluorescence assays .
    NH2-PEG4-DOTA
  • HY-W782078
    Butyne-DOTA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.
    Butyne-DOTA
  • HY-W717779
    4-Aminobutyl-DOTA

    		Biochemical Assay Reagents Others
    4-Aminobutyl-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA can be used for conjugation of peptides and radionuclides.
    4-Aminobutyl-DOTA
  • HY-A0074
    DTPA-tetra (t-Bu ester)

    tetra-tBu-DTPA

    		 Biochemical Assay Reagents Others
    DTPA-tetra (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. DTPA-tetra (t-Bu ester) can be used for conjugation of peptides and radionuclides.
    DTPA-tetra (t-Bu ester)
  • HY-W717800A
    NO2A-Azide trihydrochloride

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    NO2A-Azide (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Azide (trihydrochloride) can be used for conjugation of peptides and radionuclides.
    NO2A-Azide trihydrochloride
  • HY-159180
    p-NCS-Bz-NODA-GA

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    p-NCS-Bz-NODA-GA is a bifunctional chelator.
    p-NCS-Bz-NODA-GA
  • HY-W004649
    Tris-BOC-cyclen

    		Biochemical Assay Reagents Others
    Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
    Tris-BOC-cyclen
  • HY-158072
    DOTAM-NHS-ester

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Cancer
    DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development .
    DOTAM-NHS-ester
  • HY-P10913
    HYNIC-UBI29-41

    		Bacterial Infection
    HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364) (HY-P10364). HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .
    HYNIC-UBI29-41
  • HY-W717830
    CB-Cyclam

    		Biochemical Assay Reagents Others
    CB-Cyclamis a bifunctional chelator (Bifunctional Chelator; BFC), which is a main chain Cyclen derivative of the macrocyclic ligand tetradecane. CB-Cyclam can be used for conjugation of peptides and radionuclides.
    CB-Cyclam
  • HY-W451440
    Butyne-DOTA-tris(t-butyl ester)

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    Butyne-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
    Butyne-DOTA-tris(t-butyl ester)
  • HY-158066
    p-NH2-Bn-NOTA hydrochloride hydrate

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    p-NH2-Bn-NOTA (hydrochloride hydrate)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. p-NH2-Bn-NOTA (hydrochloride hydrate) can be used for conjugation of peptides and radionuclides.
    p-NH2-Bn-NOTA hydrochloride hydrate
  • HY-156035
    Bz-DTPA
    1 Publications Verification

    		 Biochemical Assay Reagents Inflammation/Immunology
    Bz-DTPA is a bifunctional chelator. Bz-DTPA can be used for preparing immunoconjugate of monoclonal antibody 2G3 labeled with indium-111 .
    Bz-DTPA
  • HY-164576
    NCS-MP-NODA

    NODA-Bz-SCN

    		 Radionuclide-Drug Conjugates (RDCs) Cancer
    NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.
    NCS-MP-NODA
  • HY-131673A
    (S)-p-SCN-Bn-TCMC hydrochloride

    		Biochemical Assay Reagents Others
    (S)-p-SCN-Bn-TCMC (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-TCMC (hydrochloride) can be used for conjugation of peptides and radionuclides.
    (S)-p-SCN-Bn-TCMC hydrochloride
  • HY-148646A
    p-NH2-CHX-A"-DTPA hydrochloride hydrate

    		Biochemical Assay Reagents Others
    p-NH2-CHX-A"-DTPA (hydrochloride hydrate)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH2-CHX-A"-DTPA (hydrochloride hydrate) can be used for conjugation of peptides and radionuclides.
    p-NH2-CHX-A
  • HY-12691
    BFCAs-1

    		Biochemical Assay Reagents Cancer
    BFCAs-1 is a bifunctional chelator commonly used in medical imaging and biochemistry.
    BFCAs-1
  • HY-153551A
    HBED-CC-tris(tert-butyl ester) TFA

    		Biochemical Assay Reagents Others
    HBED-CC-tris(tert-butyl ester) TFA is a derivative of HBED-CC and a bifunctional chelator. HBED-CC-tris(tert-butyl ester) TFA can be used in the research of radiolabeling and compounds for tumor-assisted diagnosis .
    HBED-CC-tris(tert-butyl ester) TFA
  • HY-131673
    p-SCN-Bn-TCMC tetrahydrochloride

    		Biochemical Assay Reagents Others
    p-SCN-Bn-TCMC tetrahydrochloride is a bifunctional chelator that exhibits high reactivity due to its powerful TCMC component, making it effective for binding radio-isotopic heavy metal ions, which are essential in radio-diagnostic imaging applications.
    p-SCN-Bn-TCMC tetrahydrochloride
  • HY-W005561
    H-Dab(Boc)-OMe hydrochloride

    		Amino Acid Derivatives Others
    H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
    H-Dab(Boc)-OMe hydrochloride
  • HY-W011118
    DTPA anhydride

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    DTPA anhydride is a bifunctional chelator whose anhydride can react with amino groups in proteins (such as lysine residues) to form stable amide bonds. DTPA anhydride can also bind to radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.
    DTPA anhydride
  • HY-164591
    THP(Bz)3-NH2

    		Radionuclide-Drug Conjugates (RDCs) Cancer
    THP(Bz)3-NH2 is a bifunctional chelator that can be conjugated with radionuclides to prepare radionuclide conjugates (RDCs) .
    THP(Bz)3-NH2
  • HY-138134
    NOTP

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) MOFs Others
    NOTPis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTP can be used for conjugation of peptides and radionuclides.
    NOTP
  • HY-W088413
    DOTA-amide

    		Biochemical Assay Reagents Others
    DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.
    DOTA-amide
  • HY-158070
    Diamsar hydrochloride

    		Biochemical Assay Reagents Others
    Diamsar hydrochloride is a bifunctional chelator .
    Diamsar hydrochloride
  • HY-W250844A
    DO3A trisodium

    		Biochemical Assay Reagents Others
    DO3A (trisodium)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO3A (trisodium) can be used for conjugation of peptides and radionuclides.
    DO3A trisodium
  • HY-128890A
    DOTA-NHS-ester hexafluorophosphate TFA

    		Biochemical Assay Reagents Others
    DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.
    DOTA-NHS-ester hexafluorophosphate TFA
  • HY-W782087A
    p-SCN-Bn-PCTA hydrochloride

    		Biochemical Assay Reagents Others
    p-SCN-Bn-PCTA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-SCN-Bn-PCTA (hydrochloride) can be used for conjugation of peptides and radionuclides.
    p-SCN-Bn-PCTA hydrochloride
  • HY-156138A
    CB-TE2A tetrahydrochloride

    		Biochemical Assay Reagents Others
    CB-TE2A (tetrahydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC), which is a TETA derivative of the macrocyclic ligand tetradecane backbone. CB-TE2A (tetrahydrochloride) can be used for conjugation of peptides and radionuclides.
    CB-TE2A tetrahydrochloride
  • HY-W283556
    DO2A-tert-butyl ester

    		Biochemical Assay Reagents Cancer
    DO2A-tert-butyl ester is a bifunctional chelator (BFC) that can be used for the coupling of peptides and radionuclides. DO2A-tert-butyl ester can be used in the development of radionuclide imaging tracers .
    DO2A-tert-butyl ester
  • HY-P10913A
    HYNIC-UBI29-41 TFA

    		Bacterial Infection
    HYNIC-UBI29-41 TFA is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41 (HY-P10364). HYNIC-UBI29-41 TFA retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 TFA can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .
    HYNIC-UBI29-41 TFA
  • HY-171561
    DOTAM-Maleimide triTFA

    		Biochemical Assay Reagents Others
    DOTAM-Maleimide triTFA is a bifunctional chelator, combining the DOTAM structure with a maleimide group for efficient thiol coupling. DOTAM-Maleimide triTFA forms stable complexes with radiometals, promising for applications in molecular imaging and radiotherapy .
    DOTAM-Maleimide triTFA
  • HY-138269A
    Barzuxetan hydrochloride

    CHX-A''-DTPA-NCS hydrochloride

    		 Biochemical Assay Reagents Others
    Barzuxetan (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Barzuxetan (hydrochloride) can be used for conjugation of peptides and radionuclides.
    Barzuxetan hydrochloride
  • HY-134418A
    NOTA trihydrochloride

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Others
    NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.
    NOTA trihydrochloride
  • HY-W717782
    Bz-DTPA hydrochloride

    		Biochemical Assay Reagents Others
    Bz-DTPA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Bz-DTPA (hydrochloride) can be used for conjugation of peptides and radionuclides.
    Bz-DTPA hydrochloride
  • HY-W726767
    DO2A

    		Biochemical Assay Reagents Others
    DO2Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO2A can be used for conjugation of peptides and radionuclides.
    DO2A

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