p-NCS-Bz-DOTA-GA
Based on 1 Customer Validation
p-NCS-Bz-DOTA-GA is a bifunctional chelator. p-NCS-Bz-DOTA-GA can be used as a versatile linker in targeted molecular imaging for both PET/SPECT and MRI applications.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.93%
- CAS 番号: 2194580-71-5
- 分子式: C27H38N6O9S
- 分子量:622.69
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
p-NCS-Bz-DOTA-GA (0.1-10 μM, 60 min) can be conjugated to human serum albumin (HSA) via lysine coupling to evaluate the in vivo stability of the resultant constructs[1].
p-NCS-Bz-DOTA-GA can be used in the synthesis of an MRI contrast agent targeting extradomain B fibronectin (EDB-FN), to enable prostate cancer imaging[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2194580-71-5
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性状 Solid
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分子量 622.69
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分子式 C27H38N6O9S
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Color White to off-white
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SMILES
O=C(C(CCC(NCC1=CC=C(N=C=S)C=C1)=O)N2CCN(CCN(CCN(CC2)CC(O)=O)CC(O)=O)CC(O)=O)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (160.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cassells I, et al. Radiolabeling of Human Serum Albumin With Terbium-161 Using Mild Conditions and Evaluation of in vivo Stability. Front Med (Lausanne). 2021 Aug 18;8:675122. [Content Brief]
[2]. Li Y, et al. Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer. Mol Pharm. 2017 Nov 6;14(11):3906-3915. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6059 mL | 8.0297 mL | 16.0594 mL | 40.1484 mL |
| 5 mM | 0.3212 mL | 1.6059 mL | 3.2119 mL | 8.0297 mL | |
| 10 mM | 0.1606 mL | 0.8030 mL | 1.6059 mL | 4.0148 mL | |
| 15 mM | 0.1071 mL | 0.5353 mL | 1.0706 mL | 2.6766 mL | |
| 20 mM | 0.0803 mL | 0.4015 mL | 0.8030 mL | 2.0074 mL | |
| 25 mM | 0.0642 mL | 0.3212 mL | 0.6424 mL | 1.6059 mL | |
| 30 mM | 0.0535 mL | 0.2677 mL | 0.5353 mL | 1.3383 mL | |
| 40 mM | 0.0401 mL | 0.2007 mL | 0.4015 mL | 1.0037 mL | |
| 50 mM | 0.0321 mL | 0.1606 mL | 0.3212 mL | 0.8030 mL | |
| 60 mM | 0.0268 mL | 0.1338 mL | 0.2677 mL | 0.6691 mL | |
| 80 mM | 0.0201 mL | 0.1004 mL | 0.2007 mL | 0.5019 mL | |
| 100 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.4015 mL |
p-NCS-Bz-DOTA-GA 関連分類
HY-159181 関連分類
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