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Cat. No.: HY-126437H

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Poly-L-lysine hydrobromide (MW 4000-15000)

Name: Poly-L-lysine hydrobromide (MW 4000-15000)
Brand: MedChemExpress
SKU: HY-126437H
Price: 80.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Poly-L-lysine hydrobromide (MW 4000-15000) is a positively charged amino acid polymer that acts as a non-specific attachment factor for cells. Poly-L-lysine hydrobromide (MW 4000-15000) enhances the electrostatic interaction between the negative ions of the cell membrane and the surface of the culture medium, thereby promoting the adhesion of cells to solid substrates. Poly-L-lysine hydrobromide (MW 4000-15000) can be used for gene delivery.

For research use only. We do not sell to patients.

CAS No.: 25988-63-0
Formula: C₈H₁₉BrN₂O
Molecular Weight:4000-15000

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Poly-L-lysine hydrobromide (MW 4000-15000) Chemical Structure

CAS No.: 25988-63-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
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Biological Activity

Description

In Vitro

Poly-L-lysine hydrobromide (MW 4000-15000) is used as a base coating reagent for cell culture in the cell surface labeling experiment. It promotes the adhesion of HEK293T cells on glass slides, ensuring the feasibility and accuracy of the experiment^[1].
Poly-L-lysine hydrobromide (MW 4000-15000) forms a complex (polyplex) by electrostatic interaction with negatively charged plasmid DNA (pDNA), thereby introducing genes into cells. In the presence of CaCl₂, the low molecular weight (MW 1000-5000) (HY-126437I) achieves the most efficient gene transfection while maintaining the lowest cytotoxicity, making it an ideal safe and efficient vector^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 25988-63-0
Appearance Solid
Molecular Weight 4000-15000
Formula C₈H₁₉BrN₂O
Color White to off-white
SMILES

CN[C@@H](CCCC[NH3+])C(C)=O.[n].[Br-].[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

J Neuroinflammation

Soluble CSF1R alleviates microgliopathy in a CSF1R-related leukoencephalopathy (CRL) mouse model. [Abstract]

2025 Dec 5. PMID: 41350870

Solvent & Solubility

In Vitro:

DMSO : 4.17 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhou Y, et al. Soluble CSF1R alleviates microgliopathy in a CSF1R-related leukoencephalopathy (CRL) mouse model. J Neuroinflammation. 2025 Dec 5;23(1):12. [Content Brief]

[2]. Xie SX, et al. Calcium enhances gene expression when using low molecular weight poly-l-lysine delivery vehicles. Int J Pharm. 2018 Aug 25;547(1-2):274-281. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Poly-L-lysine hydrobromide (MW 4000-15000)

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Poly-L-lysine hydrobromide (MW 4000-15000)

Publications Citing Use of MedChemExpress (MCE) Poly-L-lysine hydrobromide (MW 4000-15000)