DOTA-Thiol
Based on 1 Customer Validation
DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 865470-67-3
- Formula: C18H33N5O7S
- Molecular Weight:463.55
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Chemical Information
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CAS No. 865470-67-3
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Appearance Solid
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Molecular Weight 463.55
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Formula C18H33N5O7S
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Color White to off-white
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SMILES
O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(NCCS)=O)CC(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (539.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (215.73 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.1573 mL | 10.7863 mL | 21.5726 mL | 53.9316 mL |
| 5 mM | 0.4315 mL | 2.1573 mL | 4.3145 mL | 10.7863 mL | |
| 10 mM | 0.2157 mL | 1.0786 mL | 2.1573 mL | 5.3932 mL | |
| 15 mM | 0.1438 mL | 0.7191 mL | 1.4382 mL | 3.5954 mL | |
| 20 mM | 0.1079 mL | 0.5393 mL | 1.0786 mL | 2.6966 mL | |
| 25 mM | 0.0863 mL | 0.4315 mL | 0.8629 mL | 2.1573 mL | |
| 30 mM | 0.0719 mL | 0.3595 mL | 0.7191 mL | 1.7977 mL | |
| 40 mM | 0.0539 mL | 0.2697 mL | 0.5393 mL | 1.3483 mL | |
| 50 mM | 0.0431 mL | 0.2157 mL | 0.4315 mL | 1.0786 mL | |
| 60 mM | 0.0360 mL | 0.1798 mL | 0.3595 mL | 0.8989 mL | |
| 80 mM | 0.0270 mL | 0.1348 mL | 0.2697 mL | 0.6741 mL | |
| 100 mM | 0.0216 mL | 0.1079 mL | 0.2157 mL | 0.5393 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.