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  4. DOTA-NHS-ester hexafluorophosphate TFA

DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.

For research use only. We do not sell to patients.

CAS No. : 1823122-52-6

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE DOTA-NHS-ester hexafluorophosphate TFA

In Vivo Efficacy Study

    DOTA-NHS-ester hexafluorophosphate TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

    PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. PSP@Ab@PEG exhibited increased blood circulation in BALB/c mice with blood clearance half-life periods found to be 12 min.

    DOTA-NHS-ester hexafluorophosphate TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

    PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. More PSP–NH2 accumulated in the liver site while a lot more PSP@Ab@PEG accumulated in the spleen.

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    Description

    DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.

    Molecular Weight

    761.48

    Formula

    C20H31N5O10.C2HF3O2.F6P.H
    CAS No.
    SMILES

    O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(ON2C(CCC2=O)=O)=O)CC(O)=O)O.O=C(C(F)(F)F)O.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[H+]
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    Room temperature in continental US; may vary elsewhere.
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    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    DOTA-NHS-ester hexafluorophosphate TFA Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    DOTA-NHS-ester hexafluorophosphate1823122-52-6Biochemical Assay ReagentsInhibitorinhibitorinhibit

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