1823122-52-6
Chemical Structure
DOTA-NHS-ester hexafluorophosphate TFA
- CAS No.: 1823122-52-6
- Formula:C20H31N5O10.C2HF3O2.F6P.H
- Molecular Weight:761.48
InChIKey: NGLVUOKEPPQYJQ-UHFFFAOYSA-O
SMILES: O=C(CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(ON2C(CCC2=O)=O)=O)CC(O)=O)O.O=C(C(F)(F)F)O.[F-][P+5]([F-])([F-])([F-])([F-])[F-].[H+]
Biological Activity: DOTA-NHS-ester hexafluorophosphate TFA is a bifunctional reagent containing a DOTA chelating group and an NHS ester. DOTA-NHS-ester hexafluorophosphate TFA can be conjugated to proteins/antibodies/HSA via primary amino groups for radiolabeling with radiometals, and when combined with 16-amino-1-hexadecanethiol hydrochloride, it enables the construction of self-assembled monolayers on gold surfaces for lectin microarrays. DOTA-NHS-ester hexafluorophosphate TFA can be used to prepare DOTA-HSA-Z (HER2:342) imaging probes, as well as to construct Trop2-targeted radiotherapeutic and diagnostic probes for pancreatic cancer[1][2][3].
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DOTA-NHS-ester hexafluorophosphate TFA | DOTA-NHS-ester hexafluorophosphate TFA is a bifunctional reagent containing a DOTA chelating group and an NHS ester. DOTA-NHS-ester hexafluorophosphate TFA can be conjugated to proteins/antibodies/HSA via primary amino groups for radiolabeling with radiometals, and when combined with 16-amino-1-hexadecanethiol hydrochloride, it enables the construction of self-assembled monolayers on gold surfaces for lectin microarrays. DOTA-NHS-ester hexafluorophosphate TFA can be used to prepare DOTA-HSA-Z (HER2:342) imaging probes, as well as to construct Trop2-targeted radiotherapeutic and diagnostic probes for pancreatic cancer. | |||||||||||||||||||||
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References
- [1]. Hoppmann S, et al. Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting. Bioconjugate chemistry. 2011 Mar 16;22(3):413-21. [Content Brief]
- [2]. Gao Y, et al. Establishment of a 1, 4, 7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono-N-hydroxysuccinimide ester (DOTA-NHS-ester) based lectin microarray for efficiently detecting serum glycans in gastric cancers. Analytical biochemistry. 2020 May 15;597:113686.
- [3]. Li C, et al. Theranostic application of Cu/Lu-labeled anti-Trop2 monoclonal antibody in pancreatic cancer tumor models. European journal of nuclear medicine and molecular imaging. 2022 Dec;50(1):168-183. [Content Brief]
