2. Antibody-drug Conjugate/ADC Related Others
  3. ADC Linker Biochemical Assay Reagents
  4. DOTA-​NHS-ester TFA

DOTA-​NHS-ester (TFA) is used as a linker for affibody molecules, and it can be employed in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. DOTA-​NHS-ester can be used to label radiotracers or imaging probes for tumor detection.

For research use only. We do not sell to patients.

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DOTA-​NHS-ester TFA:

DOTA-​NHS-ester TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DOTA-​NHS-ester TFA

In Vivo Efficacy Study

    DOTA-​NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

    PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. PSP@Ab@PEG exhibited increased blood circulation in BALB/c mice with blood clearance half-life periods found to be 12 min.

    DOTA-​NHS-ester TFA purchased from MedChemExpress. Usage Cited in: Adv Nanobiomed Res. 2023 Sep 3.

    PSP–NH2 was incubated with DOTA–NHS–ester for 1 h and conjugated with mPEG–NHS. Then, the particles were mixed with 64Cu (OAc)2 at 50 ℃ for 1 h to obtain the 64Cu-labelled PSP. More PSP–NH2 accumulated in the liver site while a lot more PSP@Ab@PEG accumulated in the spleen.

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    Description

    DOTA-​NHS-ester (TFA) is used as a linker for affibody molecules, and it can be employed in small animal positron emission tomography (PET), single photon emission computed tomography (SPECT), and CT scanning. DOTA-​NHS-ester can be used to label radiotracers or imaging probes for tumor detection[1].

    Molecular Weight

    615.51

    Formula

    C22H32F3N5O12
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC(C(F)(F)F)=O.O=C(ON1C(CCC1=O)=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (203.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6247 mL 8.1233 mL 16.2467 mL
    5 mM 0.3249 mL 1.6247 mL 3.2493 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 95.0%

    SDS (251 KB)

    COA (249 KB) HNMR (285 KB) MS (72 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6247 mL 8.1233 mL 16.2467 mL 40.6167 mL
    5 mM 0.3249 mL 1.6247 mL 3.2493 mL 8.1233 mL
    10 mM 0.1625 mL 0.8123 mL 1.6247 mL 4.0617 mL
    15 mM 0.1083 mL 0.5416 mL 1.0831 mL 2.7078 mL
    20 mM 0.0812 mL 0.4062 mL 0.8123 mL 2.0308 mL
    25 mM 0.0650 mL 0.3249 mL 0.6499 mL 1.6247 mL
    30 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.3539 mL
    40 mM 0.0406 mL 0.2031 mL 0.4062 mL 1.0154 mL
    50 mM 0.0325 mL 0.1625 mL 0.3249 mL 0.8123 mL
    60 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6769 mL
    80 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.5077 mL
    100 mM 0.0162 mL 0.0812 mL 0.1625 mL 0.4062 mL
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    DOTA-​NHS-ester TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DOTA-​NHS-esterADC LinkerBiochemical Assay ReagentsAntibody-drug conjugates linkerTumor detectionInhibitorinhibitorinhibit

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