DOTA-GA-maleimide
Based on 1 Customer Validation
DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with 111In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling 111In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 1800229-46-2
- Formula: C25H38N6O11
- Molecular Weight:598.60
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Bifunctional Chelator |
Maleimide-DOTA-GA conjugated, 111In-radiolabeled LFn (60 nM; 2 h) exhibits significantly enhanced cell-binding capacity in MMP-positive HT-1080 cells when used in combination with PA-L1; among these, the uptake of the direct radiolabeled form ([111In]In-DOTA-GA-LFndir) is higher than that of the pre-labeled form[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1800229-46-2
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Appearance Solid
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Molecular Weight 598.60
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Formula C25H38N6O11
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Color White to off-white
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SMILES
O=C(CN1CCN(CCN(C(CCC(NCCN2C(C=CC2=O)=O)=O)C(O)=O)CCN(CC1)CC(O)=O)CC(O)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H2O : 250 mg/mL (417.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6706 mL | 8.3528 mL | 16.7056 mL | 41.7641 mL |
| 5 mM | 0.3341 mL | 1.6706 mL | 3.3411 mL | 8.3528 mL | |
| 10 mM | 0.1671 mL | 0.8353 mL | 1.6706 mL | 4.1764 mL | |
| 15 mM | 0.1114 mL | 0.5569 mL | 1.1137 mL | 2.7843 mL | |
| 20 mM | 0.0835 mL | 0.4176 mL | 0.8353 mL | 2.0882 mL | |
| 25 mM | 0.0668 mL | 0.3341 mL | 0.6682 mL | 1.6706 mL | |
| 30 mM | 0.0557 mL | 0.2784 mL | 0.5569 mL | 1.3921 mL | |
| 40 mM | 0.0418 mL | 0.2088 mL | 0.4176 mL | 1.0441 mL | |
| 50 mM | 0.0334 mL | 0.1671 mL | 0.3341 mL | 0.8353 mL | |
| 60 mM | 0.0278 mL | 0.1392 mL | 0.2784 mL | 0.6961 mL | |
| 80 mM | 0.0209 mL | 0.1044 mL | 0.2088 mL | 0.5221 mL | |
| 100 mM | 0.0167 mL | 0.0835 mL | 0.1671 mL | 0.4176 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DOTA-GA-maleimide Related Classifications
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