THP(Bz)3-NH2

Cat. No.: HY-164591: Data Sheet Handling Instructions
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THP(Bz)3-NH2 is a bifunctional chelator that can be conjugated with radionuclides to prepare radionuclide conjugates (RDCs).

For research use only. We do not sell to patients.

THP(Bz)3-NH2 Chemical Structure

CAS No. : 827331-42-0

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Description

THP(Bz)3-NH2 is a bifunctional chelator that can be conjugated with radionuclides to prepare radionuclide conjugates (RDCs)^[1].

IC₅₀ & Target^[1]

RDC Bifunctional Chelator

In Vitro

THP(Bz)3-NH2 is a precursor compound for synthesis of the tris(hydroxypyridinone) bifunctional chelator H3THP-NCS^[1].
THP(Bz)3-NH2 supports conjugation of H3THP-NCS to αvβ3 integrin-targeting peptide RGD for ⁶⁸Ga³⁺ radiolabeling to generate PET imaging agents^[1].
RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1039.22

Formula

C₅₈H₇₀N₈O₁₀

CAS No.

827331-42-0

SMILES

O=C1C=C(C)N(C)C(CNC(CCC(CCC(NCC2=C(C(C=C(C)N2C)=O)OCC3=CC=CC=C3)=O)(CCC(NCC4=C(C(C=C(C)N4C)=O)OCC5=CC=CC=C5)=O)NC(CCN)=O)=O)=C1OCC6=CC=CC=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ma MT, et al. New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One-Step Labeling and PET Imaging with (68)Ga(3.). Bioconjug Chem. 2016;27(2):309-318.

THP(Bz)3-NH2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THP(Bz)3-NH2827331-42-0Radionuclide-Drug Conjugates (RDCs)bifunctional chelatorPET imagingInhibitorinhibitorinhibit

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