NH2-UAMC1110
Based on 1 Customer Validation
NH2-UAMC1110 is an aminobutoxy derivative of the fibroblast activation protein (FAP) inhibitor UAMC1110 (HY-100684), and is a precursor compound for the synthesis of FAP inhibitor probes, not directly used in bioactivity experiments. For example, NH2-UAMC1110 is involved in the synthesis of the radiotracer FAPI-QS, which exhibits high tumor selectivity and high dose-response, and has been used for tumor diagnosis. NH2-UAMC1110 introduces an active amino group into its structure, enabling it to form covalent bonds with various molecules (such as DOTA, DATA5m, radionuclide chelators, etc.), thereby synthesizing molecular imaging probes or targeted compounds with the ability to target FAP. NH2-UAMC1110 specifically binds to the FAP active site, inhibiting its proline-selective serine protease activity (including dipeptidyl peptidase and endopeptidase activity), blocking FAP-mediated tissue remodeling processes. Its key activity is high targeting and high affinity, and its core function is to be coupled with bifunctional chelators (such as DOTA, DATA5m) as a targeting module. NH2-UAMC1110 can be applied to diagnostic imaging studies of tumors expressing FAP (such as colorectal cancer, pancreatic cancer, etc.), and also provides molecular tools for targeted research of FAP-related diseases with high FAP expression, such as fibrosis and arthritis.
For research use only. We do not sell to patients.
- Purity : 99.86%
- CAS No.: 2758337-19-6
- Formula: C21H23F2N5O3
- Molecular Weight:431.44
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
NH2-UAMC1110 was coupled with DOTA.SA in phosphate buffer at pH 9 to successfully synthesize the FAP-targeting probe DOTA.SA.FAPi. The product was purified by HPLC to achieve the required purity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2758337-19-6
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Appearance Solid
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Molecular Weight 431.44
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Formula C21H23F2N5O3
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Color White to off-white
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SMILES
O=C(N1[C@@H](CC(F)(C1)F)C#N)CNC(C2=CC=NC3=C2C=C(OCCCCN)C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (115.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3178 mL | 11.5891 mL | 23.1782 mL | 57.9455 mL |
| 5 mM | 0.4636 mL | 2.3178 mL | 4.6356 mL | 11.5891 mL | |
| 10 mM | 0.2318 mL | 1.1589 mL | 2.3178 mL | 5.7945 mL | |
| 15 mM | 0.1545 mL | 0.7726 mL | 1.5452 mL | 3.8630 mL | |
| 20 mM | 0.1159 mL | 0.5795 mL | 1.1589 mL | 2.8973 mL | |
| 25 mM | 0.0927 mL | 0.4636 mL | 0.9271 mL | 2.3178 mL | |
| 30 mM | 0.0773 mL | 0.3863 mL | 0.7726 mL | 1.9315 mL | |
| 40 mM | 0.0579 mL | 0.2897 mL | 0.5795 mL | 1.4486 mL | |
| 50 mM | 0.0464 mL | 0.2318 mL | 0.4636 mL | 1.1589 mL | |
| 60 mM | 0.0386 mL | 0.1932 mL | 0.3863 mL | 0.9658 mL | |
| 80 mM | 0.0290 mL | 0.1449 mL | 0.2897 mL | 0.7243 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2318 mL | 0.5795 mL |
NH2-UAMC1110 Related Classifications
HY-153552 Related Classifications
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