p-SCN-Bn-PCTA hydrochloride
p-SCN-Bn-PCTA hydrochloride is a Bifunctional Chelator used for radiometal labeling. p-SCN-Bn-PCTA hydrochloride can conjugate with peptides or antibodies via its isothiocyanate group. PCTA-RGD, formed by the conjugation of p-SCN-Bn-PCTA with cyclo-RGDyK, retains binding activity towards αvβ3 integrin with an IC50 of 1.8 μM. p-SCN-Bn-PCTA hydrochloride can be used for the construction of PET radiotracers and imaging studies related to pancreatic cancer, colorectal cancer, and tumor angiogenesis.
For research use only. We do not sell to patients.
- CAS No.: 2649490-34-4
- Formula: C25H32Cl3N5O6S
- Molecular Weight:636.98
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
More
Biological Activity
p-SCN-Bn-PCTA (1.1 equiv; room temperature; overnight) hydrochloride can conjugate with cyclo-RGDyK via the isothiocyanate group to form PCTA-RGD, whose IC50 for binding to αvβ3 integrin in U87MG cells is 1.8 μM[2].
PCTA-RGD formed from p-SCN-Bn-PCTA hydrochloride achieves a radiochemical yield of 95.2% for 68Ga when labeled at room temperature for 5 min, and reaches a radiochemical yield of 97.1% when labeled at 40 °C for 5 min[2].
p-SCN-Bn-PCTA (chelator:antibody = 5:1; 37 °C; overnight) hydrochloride conjugates with NCAB001 to form PCTA-NCAB001, with an average of 3 PCTA molecules conjugated per NCAB001 molecule, and PCTA-NCAB001 retains EGFR-binding activity comparable to that of cetuximab[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2649490-34-4
-
Molecular Weight 636.98
-
Formula C25H32Cl3N5O6S
-
SMILES
OC(CN(CC1=CC=CC(CN(CCN(C2)CC(O)=O)CC(O)=O)=N1)[C@H]2CC3=CC=C(C=C3)N=C=S)=O.Cl.Cl.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Matsumoto H, et al. Characterization and Stabilization of a New Cu-Labeled Anti-EGFR Antibody NCAB001 for the Early Detection of Pancreatic Cancer with Positron Emission Tomography. Pharmaceutics. 2021 Dec 28;14(1):67. [Content Brief]
[2]. Ferreira CL, et al. 68Ga Small Peptide Imaging: Comparison of NOTA and PCTA. Bioconjug Chem. 2012;23:2239-2246. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
p-SCN-Bn-PCTA hydrochloride Related Classifications
HY-W782087A Related Classifications
Powered by Bioz