2649490-34-4
Chemical Structure
p-SCN-Bn-PCTA hydrochloride
- CAS No.: 2649490-34-4
- Formula:C25H32Cl3N5O6S
- Molecular Weight:636.98
InChIKey: OKAAFRRYKFQFDW-NNUMAELLSA-N
SMILES: OC(CN(CC1=CC=CC(CN(CCN(C2)CC(O)=O)CC(O)=O)=N1)[C@H]2CC3=CC=C(C=C3)N=C=S)=O.Cl.Cl.Cl
Biological Activity: p-SCN-Bn-PCTA hydrochloride is a Bifunctional Chelator used for radiometal labeling. p-SCN-Bn-PCTA hydrochloride can conjugate with peptides or antibodies via its isothiocyanate group. PCTA-RGD, formed by the conjugation of p-SCN-Bn-PCTA with cyclo-RGDyK, retains binding activity towards αvβ3 integrin with an IC50 of 1.8 μM. p-SCN-Bn-PCTA hydrochloride can be used for the construction of PET radiotracers and imaging studies related to pancreatic cancer, colorectal cancer, and tumor angiogenesis[1][2].
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p-SCN-Bn-PCTA hydrochloride | p-SCN-Bn-PCTA hydrochloride is a Bifunctional Chelator used for radiometal labeling. p-SCN-Bn-PCTA hydrochloride can conjugate with peptides or antibodies via its isothiocyanate group. PCTA-RGD, formed by the conjugation of p-SCN-Bn-PCTA with cyclo-RGDyK, retains binding activity towards αvβ3 integrin with an IC50 of 1.8 μM. p-SCN-Bn-PCTA hydrochloride can be used for the construction of PET radiotracers and imaging studies related to pancreatic cancer, colorectal cancer, and tumor angiogenesis. | |||||||||||||||||||||
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- [1]. Matsumoto H, et al. Characterization and Stabilization of a New Cu-Labeled Anti-EGFR Antibody NCAB001 for the Early Detection of Pancreatic Cancer with Positron Emission Tomography. Pharmaceutics. 2021 Dec 28;14(1):67. [Content Brief]
- [2]. Ferreira CL, et al. 68Ga Small Peptide Imaging: Comparison of NOTA and PCTA. Bioconjug Chem. 2012;23:2239-2246. [Content Brief]
Keywords
