Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)

Cat. No.: HY-W749603 Purity: 98.26%: Data Sheet
COA

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Handling Instructions
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Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.

For research use only. We do not sell to patients.

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) Chemical Structure

CAS No. : 479081-06-6

Size	Stock	Quantity

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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Description

IC₅₀ & Target

RDC Bifunctional Chelator

In Vitro

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) consists of four key structural parts that work synergistically to achieve its function:
DOTA backbone: This is a powerful ligand that forms extremely stable and robust complexes with metal ions such as Ga³⁺, Lu³⁺, and Gd³⁺.
Tris(t-Bu ester) (tris(t-Bu ester)): Acts as a protecting group, protecting the three carboxyl groups of DOTA.
L-Lys as a linker: DOTA is linked to the ε-amino group of lysine via its fourth carboxyl group.
Fmoc protecting group: Protects the α-amino group of lysine, allowing this compound to be seamlessly integrated into the standard Fmoc solid-phase peptide synthesis (SPPS) process as a standard amino acid building block.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

923.15

Formula

C₄₉H₇₄N₆O₁₁

CAS No.

479081-06-6

Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C)OC(CN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CCN1CC(NCCCC[C@@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (108.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0832 mL	5.4162 mL	10.8325 mL
5 mM	0.2166 mL	1.0832 mL	2.1665 mL
10 mM	0.1083 mL	0.5416 mL	1.0832 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.26%

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Data Sheet (246 KB) SDS (393 KB)

COA (249 KB) HNMR (257 KB) LCMS (113 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0832 mL	5.4162 mL	10.8325 mL	27.0812 mL
	5 mM	0.2166 mL	1.0832 mL	2.1665 mL	5.4162 mL
	10 mM	0.1083 mL	0.5416 mL	1.0832 mL	2.7081 mL
	15 mM	0.0722 mL	0.3611 mL	0.7222 mL	1.8054 mL
	20 mM	0.0542 mL	0.2708 mL	0.5416 mL	1.3541 mL
	25 mM	0.0433 mL	0.2166 mL	0.4333 mL	1.0832 mL
	30 mM	0.0361 mL	0.1805 mL	0.3611 mL	0.9027 mL
	40 mM	0.0271 mL	0.1354 mL	0.2708 mL	0.6770 mL
	50 mM	0.0217 mL	0.1083 mL	0.2166 mL	0.5416 mL
	60 mM	0.0181 mL	0.0903 mL	0.1805 mL	0.4514 mL
	80 mM	0.0135 mL	0.0677 mL	0.1354 mL	0.3385 mL
	100 mM	0.0108 mL	0.0542 mL	0.1083 mL	0.2708 mL