Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
Based on 1 Customer Validation
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
For research use only. We do not sell to patients.
- Purity : 98.26%
- CAS No.: 479081-06-6
- Formula: C49H74N6O11
- Molecular Weight:923.15
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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HY-133540
Maleimide-DOTA -
HY-100138
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) -
HY-48876
p-NH2-Bn-DOTA -
HY-W782078
Butyne-DOTA -
HY-134797
p-SCN-Bn-deferoxamine -
HY-W678394
DOTA-Thiol -
HY-W614269
DOTA-GA(tBu)4 -
HY-W087027
Maleimide-NOTA -
HY-132989
Mal-Deferoxamine -
HY-W451440
Butyne-DOTA-tris(t-butyl ester) -
HY-156035
Bz-DTPA -
HY-W717743
DOTAM-mono-acid
All Radionuclide-Drug Conjugates (RDCs) Isoforms
More
Biological Activity
Description
IC50 & Target
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RDC Bifunctional Chelator |
In Vitro
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) consists of four key structural parts that work synergistically to achieve its function:
DOTA backbone: This is a powerful ligand that forms extremely stable and robust complexes with metal ions such as Ga3+, Lu3+, and Gd3+.
Tris(t-Bu ester) (tris(t-Bu ester)): Acts as a protecting group, protecting the three carboxyl groups of DOTA.
L-Lys as a linker: DOTA is linked to the ε-amino group of lysine via its fourth carboxyl group.
Fmoc protecting group: Protects the α-amino group of lysine, allowing this compound to be seamlessly integrated into the standard Fmoc solid-phase peptide synthesis (SPPS) process as a standard amino acid building block.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 479081-06-6
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Appearance Solid
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Molecular Weight 923.15
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Formula C49H74N6O11
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Color White to off-white
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SMILES
CC(C)(C)OC(CN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CCN1CC(NCCCC[C@@H](C(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (108.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (246 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0832 mL | 5.4162 mL | 10.8325 mL | 27.0812 mL |
| 5 mM | 0.2166 mL | 1.0832 mL | 2.1665 mL | 5.4162 mL | |
| 10 mM | 0.1083 mL | 0.5416 mL | 1.0832 mL | 2.7081 mL | |
| 15 mM | 0.0722 mL | 0.3611 mL | 0.7222 mL | 1.8054 mL | |
| 20 mM | 0.0542 mL | 0.2708 mL | 0.5416 mL | 1.3541 mL | |
| 25 mM | 0.0433 mL | 0.2166 mL | 0.4333 mL | 1.0832 mL | |
| 30 mM | 0.0361 mL | 0.1805 mL | 0.3611 mL | 0.9027 mL | |
| 40 mM | 0.0271 mL | 0.1354 mL | 0.2708 mL | 0.6770 mL | |
| 50 mM | 0.0217 mL | 0.1083 mL | 0.2166 mL | 0.5416 mL | |
| 60 mM | 0.0181 mL | 0.0903 mL | 0.1805 mL | 0.4514 mL | |
| 80 mM | 0.0135 mL | 0.0677 mL | 0.1354 mL | 0.3385 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1083 mL | 0.2708 mL |
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) Related Classifications
HY-W749603 Related Classifications
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